Table 2.

Global and segmental geometric and volumetric measures

Parameter/IndexControls (n = 10)LVH Subjects (n = 10)Significance
LES, cm7.2 (0.9)7.0 (0.9)NS
LDIAST, cm8.1 (1.1)7.7 (0.9)NS
rES, cm1.6 (0.2)1.3 (0.3)NS
rDIAST, cm2.4 (0.2)2.3 (0.4)NS
VTIE, cm9.3 (1.2)9.0 (2.4)NS
Annular excursion, cm1.3 (0.3)1.0 (0.2)P < 0.01
Radial expansion Δr, cm0.9 (0.4)0.9 (0.4)NS
Wall thinning, mm*2 (1)4 (1)P < 0.001
Normalized wall thinning, %*12.1 (3.3)19.5 (6.9)P < 0.01
ΔE, mm*7 (1)5 (1)P < 0.01
Vlong, ml10.2 (3.8)5.8 (3.1)P < 0.05
Vrad, ml69.5 (22.4)62.7 (26.4)NS
%Vlong13.0 (3.4)8.8 (2.5)P < 0.01
%Vrad87.0 (3.4)91.2 (2.5)P < 0.01
  • Values are means (SD). LES and LDIAST, LV long-axis endocardial end-systolic and diastatic lengths, respectively; rES and rDIAST, LV short-axis end-systolic and diastatic radii, respectively; VTIE, E-wave velocity-time integral; Vlong and Vrad, longitudinally and radially accommodated E-wave volume components, respectively; ΔE, epicardial displacement during early filling.

  • * Wall thinning, normalized wall thinning, and ΔE were determined for 9 LVH subjects.

  • Vlong, Vrad, %Vlong, and %Vrad are based on longitudinal lengthening at constant end-systolic radius followed by radial expansion at constant diastatic length. Radial dimensions for one subject were determined from short-axis views. Note that annular excursion, wall thinning, and normalized wall thinning refer to the lateral wall only; normalized wall thinning denotes wall thinning from end-systole to diastasis divided by end-systolic lateral wall thickness.