INVITED EDITORIALS

Barbara J. Morgan

Intermittent hypoxia: keeping it real
J Appl Physiol 107: 1-3, 2009. First published March 26, 2009; doi:10.1152/japplphysiol.00304.2009 [Full Text] [PDF]  

Gladys L. Onambélé-Pearson

HRT affects skeletal muscle contractile characteristics: a definitive answer?
J Appl Physiol 107: 4-5, 2009. First published May 7, 2009; doi:10.1152/japplphysiol.00448.2009 [Full Text] [PDF]  

Michael J. Rennie, Stuart M. Phillips, and Erik A. Richter

Newton's force as countermeasure for disuse atrophy
J Appl Physiol 107: 6-7, 2009. First published May 14, 2009; doi:10.1152/japplphysiol.00499.2009 [Full Text] [PDF]  

REVIEW

Matthew M. Robinson, Karyn L. Hamilton, and Benjamin F. Miller

The interactions of some commonly consumed drugs with mitochondrial adaptations to exercise
J Appl Physiol 107: 8-16, 2009. First published May 7, 2009; doi:10.1152/japplphysiol.00343.2009 [Abstract] [Full Text] [PDF]  

ARTICLES

R. Tamisier, G. S. Gilmartin, S. H. Launois, J. L. Pépin, H. Nespoulet, R. Thomas, P. Lévy, and J. W. Weiss

A new model of chronic intermittent hypoxia in humans: effect on ventilation, sleep, and blood pressure
J Appl Physiol 107: 17-24, 2009. First published February 19, 2009; doi:10.1152/japplphysiol.91165.2008 [Abstract] [Full Text] [PDF]  

Paula H. A. Ronkainen, Vuokko Kovanen, Markku Alén, Eija Pöllänen, Eeva-Maija Palonen, Carina Ankarberg-Lindgren, Esa Hämäläinen, Ursula Turpeinen, Urho M. Kujala, Jukka Puolakka, Jaakko Kaprio, and Sarianna Sipilä

Postmenopausal hormone replacement therapy modifies skeletal muscle composition and function: a study with monozygotic twin pairs
J Appl Physiol 107: 25-33, 2009. First published February 26, 2009; doi:10.1152/japplphysiol.91518.2008 [Abstract] [Full Text] [PDF]  

T. B. Symons, M. Sheffield-Moore, D. L. Chinkes, A. A. Ferrando, and D. Paddon-Jones

Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity
J Appl Physiol 107: 34-38, 2009. First published April 23, 2009; doi:10.1152/japplphysiol.91137.2008 [Abstract] [Full Text] [PDF]  

V. J. Caiozzo, F. Haddad, S. Lee, M. Baker, William Paloski, and K. M. Baldwin

Artificial gravity as a countermeasure to microgravity: a pilot study examining the effects on knee extensor and plantar flexor muscle groups
J Appl Physiol 107: 39-46, 2009. First published March 12, 2009; doi:10.1152/japplphysiol.91130.2008 [Abstract] [Full Text] [PDF]  

S. M. Smith, S. R. Zwart, M. A. Heer, N. Baecker, H. J. Evans, A. H. Feiveson, L. C. Shackelford, and A. D. LeBlanc

Effects of artificial gravity during bed rest on bone metabolism in humans
J Appl Physiol 107: 47-53, 2009. First published December 12, 2008; doi:10.1152/japplphysiol.91134.2008 [Abstract] [Full Text] [PDF]  

S. R. Zwart, G. E. Crawford, P. L. Gillman, G. Kala, A. S. Rodgers, A. Rogers, A. M. Inniss, B. L. Rice, K. Ericson, S. Coburn, Y. Bourbeau, E. Hudson, G. Mathew, D. E. DeKerlegand, C. F. Sams, M. A. Heer, W. H. Paloski, and S. M. Smith

Effects of 21 days of bed rest, with or without artificial gravity, on nutritional status of humans
J Appl Physiol 107: 54-62, 2009. First published December 12, 2008; doi:10.1152/japplphysiol.91136.2008 [Abstract] [Full Text] [PDF]  

Natalie C. Dixon, Tina L. Hurst, Duncan C. S. Talbot, Rex M. Tyrrell, and Dylan Thompson

Active middle-aged men have lower fasting inflammatory markers but the postprandial inflammatory response is minimal and unaffected by physical activity status
J Appl Physiol 107: 63-68, 2009. First published May 7, 2009; doi:10.1152/japplphysiol.91532.2008 [Abstract] [Full Text] [PDF]  

Samuel N. Cheuvront, Shawn E. Bearden, Robert W. Kenefick, Brett R. Ely, David W. DeGroot, Michael N. Sawka, and Scott J. Montain

A simple and valid method to determine thermoregulatory sweating threshold and sensitivity
J Appl Physiol 107: 69-75, 2009. First published May 7, 2009; doi:10.1152/japplphysiol.00250.2009 [Abstract] [Full Text] [PDF]  

Nir Eynon, Moran Sagiv, Yoav Meckel, José Alberto Duarte, Alberto Jorge Alves, Chen Yamin, Michael Sagiv, Ehud Goldhammer, and José Oliveira

NRF2 intron 3 A/G polymorphism is associated with endurance athletes’ status
J Appl Physiol 107: 76-79, 2009. First published May 28, 2009; doi:10.1152/japplphysiol.00310.2009 [Abstract] [Full Text] [PDF]  

T. M. Altenburg, A. de Haan, P. W. L. Verdijk, W. van Mechelen, and C. J. de Ruiter

Vastus lateralis single motor unit EMG at the same absolute torque production at different knee angles
J Appl Physiol 107: 80-89, 2009. First published May 21, 2009; doi:10.1152/japplphysiol.90322.2008 [Abstract] [Full Text] [PDF]  

Zinta A. Zarins, Matthew L. Johnson, Nastaran Faghihnia, Michael A. Horning, Gareth A. Wallis, Jill A. Fattor, and George A. Brooks

Training improves the response in glucose flux to exercise in postmenopausal women
J Appl Physiol 107: 90-97, 2009. First published May 21, 2009; doi:10.1152/japplphysiol.91568.2008 [Abstract] [Full Text] [PDF]  

Jérôme Laurin, Erick Dousset, Serge Mesure, and Patrick Decherchi

Neuromuscular recovery pattern after medial collateral ligament disruption in rats
J Appl Physiol 107: 98-104, 2009. First published May 21, 2009; doi:10.1152/japplphysiol.00317.2009 [Abstract] [Full Text] [PDF]  

Britta S. von Ungern-Sternberg, Daniel Trachsel, Thomas O. Erb, and Jürg Hammer

Forced expiratory flows and volumes in intubated and paralyzed infants and children: normative data up to 5 years of age
J Appl Physiol 107: 105-111, 2009. First published May 14, 2009; doi:10.1152/japplphysiol.91649.2008 [Abstract] [Full Text] [PDF]  

B. W. Hoffman, T. Oya, T. J. Carroll, and A. G. Cresswell

Increases in corticospinal responsiveness during a sustained submaximal plantar flexion
J Appl Physiol 107: 112-120, 2009. First published May 14, 2009; doi:10.1152/japplphysiol.91541.2008 [Abstract] [Full Text] [PDF]  

Scott Matthew Summers, Yuichiro Hayashi, Steven Vu Nguyen, Thu Minh Nguyen, and Ralph Earl Purdy

Hindlimb unweighting induces changes in the p38^MAPK contractile pathway of the rat abdominal aorta
J Appl Physiol 107: 121-127, 2009. First published May 14, 2009; doi:10.1152/japplphysiol.00210.2009 [Abstract] [Full Text] [PDF]  

Bryon R. McKay, Donald H. Paterson, and John M. Kowalchuk

Effect of short-term high-intensity interval training vs. continuous training on O₂ uptake kinetics, muscle deoxygenation, and exercise performance
J Appl Physiol 107: 128-138, 2009. First published May 14, 2009; doi:10.1152/japplphysiol.90828.2008 [Abstract] [Full Text] [PDF]  

Bruno Degano, Marie Mittaine, Hervé Guénard, Jacques Rami, Gilles Garcia, Nassim Kamar, Christophe Bureau, Jean-Marie Péron, Lionel Rostaing, and Daniel Rivière

Nitric oxide and carbon monoxide lung transfer in patients with advanced liver cirrhosis
J Appl Physiol 107: 139-143, 2009. First published May 7, 2009; doi:10.1152/japplphysiol.91621.2008 [Abstract] [Full Text] [PDF]  

Craig A. Goodman, Deanna Horvath, Christos Stathis, Trevor Mori, Kevin Croft, Robyn M. Murphy, and Alan Hayes

Taurine supplementation increases skeletal muscle force production and protects muscle function during and after high-frequency in vitro stimulation
J Appl Physiol 107: 144-154, 2009. First published May 7, 2009; doi:10.1152/japplphysiol.00040.2009 [Abstract] [Full Text] [PDF]  

Jane Lee, Jerry Ngo, Don Blake, Simone Meinardi, Andria M. Pontello, Robert Newcomb, and Pietro R. Galassetti

Improved predictive models for plasma glucose estimation from multi-linear regression analysis of exhaled volatile organic compounds
J Appl Physiol 107: 155-160, 2009. First published May 7, 2009; doi:10.1152/japplphysiol.91657.2008 [Abstract] [Full Text] [PDF]  

Olle Lagerquist, Lee D. Walsh, Jean-Sébastien Blouin, David F. Collins, and Simon C. Gandevia

Effect of a peripheral nerve block on torque produced by repetitive electrical stimulation
J Appl Physiol 107: 161-167, 2009. First published April 23, 2009; doi:10.1152/japplphysiol.91635.2008 [Abstract] [Full Text] [PDF]  

Shlomit Radom-Aizik, Frank Zaldivar, Jr., Szu-Yun Leu, and Dan M. Cooper

A brief bout of exercise alters gene expression and distinct gene pathways in peripheral blood mononuclear cells of early- and late-pubertal females
J Appl Physiol 107: 168-175, 2009. First published April 30, 2009; doi:10.1152/japplphysiol.00121.2009 [Abstract] [Full Text] [PDF] [Supplemental Tables]  

Matthias Lange, Perenlei Enkhbaatar, Daniel L. Traber, Robert A. Cox, Sam Jacob, Babu P. Mathew, Atsumori Hamahata, Lillian D. Traber, David N. Herndon, and Hal K. Hawkins

Role of calcitonin gene-related peptide (CGRP) in ovine burn and smoke inhalation injury
J Appl Physiol 107: 176-184, 2009. First published April 30, 2009; doi:10.1152/japplphysiol.00094.2009 [Abstract] [Full Text] [PDF]  

George R. Washko, Mark T. Dransfield, Raúl San José Estépar, Alejandro Diaz, Shin Matsuoka, Tsuneo Yamashiro, Hiroto Hatabu, Edwin K. Silverman, William C. Bailey, and John J. Reilly

Airway wall attenuation: a biomarker of airway disease in subjects with COPD
J Appl Physiol 107: 185-191, 2009. First published April 30, 2009; doi:10.1152/japplphysiol.00216.2009 [Abstract] [Full Text] [PDF]  

William J. Pearce, James M. Williams, Charles R. White, and Thomas M. Lincoln

Effects of chronic hypoxia on soluble guanylate cyclase activity in fetal and adult ovine cerebral arteries
J Appl Physiol 107: 192-199, 2009. First published April 30, 2009; doi:10.1152/japplphysiol.00233.2009 [Abstract] [Full Text] [PDF]  

Tracy J. Horton, Suzanne Dow, Michael Armstrong, and W. Troy Donahoo

Greater systemic lipolysis in women compared with men during moderate-dose infusion of epinephrine and/or norepinephrine
J Appl Physiol 107: 200-210, 2009. First published April 30, 2009; doi:10.1152/japplphysiol.90812.2008 [Abstract] [Full Text] [PDF]  

Leonardo F. Ferreira, Laura A. A. Gilliam, and Michael B. Reid

L-2-Oxothiazolidine-4-carboxylate reverses glutathione oxidation and delays fatigue of skeletal muscle in vitro
J Appl Physiol 107: 211-216, 2009. First published April 30, 2009; doi:10.1152/japplphysiol.00001.2009 [Abstract] [Full Text] [PDF]  

F. J. Golder

Spinal NMDA receptor activation is necessary for de novo, but not the maintenance of, A2a receptor-mediated phrenic motor facilitation
J Appl Physiol 107: 217-223, 2009. First published April 30, 2009; doi:10.1152/japplphysiol.00183.2009 [Abstract] [Full Text] [PDF]  

Pamela J. Plant, James R. Bain, Judy E. Correa, Minna Woo, and Jane Batt

Absence of caspase-3 protects against denervation-induced skeletal muscle atrophy
J Appl Physiol 107: 224-234, 2009. First published April 23, 2009; doi:10.1152/japplphysiol.90932.2008 [Abstract] [Full Text] [PDF]  

Paola Contessa, Alexander Adam, and Carlo J. De Luca

Motor unit control and force fluctuation during fatigue
J Appl Physiol 107: 235-243, 2009. First published April 23, 2009; doi:10.1152/japplphysiol.00035.2009 [Abstract] [Full Text] [PDF]  

David J. Dubowitz, Edward A. W. Dyer, Rebecca J. Theilmann, Richard B. Buxton, and Susan R. Hopkins

Early brain swelling in acute hypoxia
J Appl Physiol 107: 244-252, 2009. First published May 7, 2009; doi:10.1152/japplphysiol.90349.2008 [Abstract] [Full Text] [PDF]  

Alexander Vol, Orna Gribova, Sylvia Berman, Yariv Siman-Tov, and Shai Efrati

Application of muscle biopotential measurement for sustained, noninvasive blood glucose survey
J Appl Physiol 107: 253-260, 2009. First published March 5, 2009; doi:10.1152/japplphysiol.90960.2008 [Abstract] [Full Text] [PDF]  

Pedro William M. Almeida, Ary Gomes-Filho, Anderson J. Ferreira, Carlos Eduardo M. Rodrigues, Marco Fabrício Dias-Peixoto, Remo C. Russo, Mauro M. Teixeira, Geovanni D. Cassali, Enio Ferreira, Ivan C. Santos, Alessandra M. C. Garcia, Emerson Silami-Garcia, Ulrik Wisløff, and Guilherme A. Pussieldi

Swim training suppresses tumor growth in mice
J Appl Physiol 107: 261-265, 2009. First published May 28, 2009; doi:10.1152/japplphysiol.00249.2009 [Abstract] [Full Text] [PDF]  

R. Scott Harris, Tilo Winkler, Guido Musch, Marcos F. Vidal Melo, Tobias Schroeder, Nora Tgavalekos, and José G. Venegas

The prone position results in smaller ventilation defects during bronchoconstriction in asthma
J Appl Physiol 107: 266-274, 2009. First published May 14, 2009; doi:10.1152/japplphysiol.91386.2008 [Abstract] [Full Text] [PDF]  

Jeremy A. Simpson, Keith R. Brunt, Christine P. Collier, and Steve Iscoe

Hyperinflation-induced cardiorespiratory failure in rats
J Appl Physiol 107: 275-282, 2009. First published April 30, 2009; doi:10.1152/japplphysiol.91342.2008 [Abstract] [Full Text] [PDF]  

Robert S. Lee-Young, Benedict J. Canny, Damian E. Myers, and Glenn K. McConell

AMPK activation is fiber type specific in human skeletal muscle: effects of exercise and short-term exercise training
J Appl Physiol 107: 283-289, 2009. First published April 9, 2009; doi:10.1152/japplphysiol.91208.2008 [Abstract] [Full Text] [PDF] [Supplemental Figures]  

INNOVATIVE METHODOLOGIES

Euhan J. Lee, Matthew E. Woodske, Baobo Zou, and Christopher P. O'Donnell

Dynamic arterial blood gas analysis in conscious, unrestrained C57BL/6J mice during exposure to intermittent hypoxia
J Appl Physiol 107: 290-294, 2009. First published December 4, 2008; doi:10.1152/japplphysiol.91255.2008 [Abstract] [Full Text] [PDF]  

Tanveer Ahmad, Ulaganathan Mabalirajan, Duraisamy Arul Joseph, Lokesh Makhija, Vijay Pal Singh, Balaram Ghosh, and Anurag Agrawal

Exhaled nitric oxide estimation by a simple and efficient noninvasive technique and its utility as a marker of airway inflammation in mice
J Appl Physiol 107: 295-301, 2009. First published April 30, 2009; doi:10.1152/japplphysiol.00235.2009 [Abstract] [Full Text] [PDF] [Supplemental Figures and Tables]  

Josef A. Vogt, Ulrich Wachter, Jürgen Mehring, Peter Radermacher, Michael Georgieff, Heinz Fischer, Uvo Hölscher, Michael Moede, and Walter Fabinski

Adaptation of the NDIR technology to ¹³CO₂ breath tests under increased inspiratory O₂ concentrations
J Appl Physiol 107: 302-307, 2009. First published May 14, 2009; doi:10.1152/japplphysiol.90913.2008 [Abstract] [Full Text] [PDF] [Supplemental Material]  

HIGHLIGHTED TOPICS

André De Troyer and Martin J. Tobin

Introducing the Highlighted Topic series
J Appl Physiol 107: 308-308, 2009. First published May 14, 2009; doi:10.1152/japplphysiol.00496.2009 [Full Text] [PDF]  

Stephen H. Loring, Mauricio Garcia-Jacques, and Atul Malhotra

Pulmonary characteristics in COPD and mechanisms of increased work of breathing
J Appl Physiol 107: 309-314, 2009. First published April 9, 2009; doi:10.1152/japplphysiol.00008.2009 [Abstract] [Full Text] [PDF]  

André De Troyer and Theodore A. Wilson

Effect of acute inflation on the mechanics of the inspiratory muscles
J Appl Physiol 107: 315-323, 2009. First published March 5, 2009; doi:10.1152/japplphysiol.91472.2008 [Abstract] [Full Text] [PDF]  

Thomas L. Clanton and Sanford Levine

Respiratory muscle fiber remodeling in chronic hyperinflation: dysfunction or adaptation?
J Appl Physiol 107: 324-335, 2009. First published April 9, 2009; doi:10.1152/japplphysiol.00173.2009 [Abstract] [Full Text] [PDF]  

Lindell K. Weaver, Steve Howe, Gregory L. Snow, and Kayla Deru

Arterial and pulmonary arterial hemodynamics and oxygen delivery/extraction in normal humans exposed to hyperbaric air and oxygen
J Appl Physiol 107: 336-345, 2009. First published April 30, 2009; doi:10.1152/japplphysiol.91012.2008 [Abstract] [Full Text] [PDF] [Supplemental Figures and Tables]  

Estelle Habouzit, Hélène Richard, Hervé Sanchez, Nathalie Koulmann, Bernard Serrurier, Rachel Monnet, Renée Ventura-Clapier, and Xavier Bigard

Decreased muscle ACE activity enhances functional response to endurance training in rats, without change in muscle oxidative capacity or contractile phenotype
J Appl Physiol 107: 346-353, 2009. First published April 30, 2009; doi:10.1152/japplphysiol.91443.2008 [Abstract] [Full Text] [PDF]  

POINT-COUNTERPOINT

Janet L. Taylor

Point:Counterpoint: The interpolated twitch does/does not provide a valid measure of the voluntary activation of muscle
J Appl Physiol 107: 354-355, 2009. First published September 18, 2008; doi:10.1152/japplphysiol.91220.2008 [Full Text] [PDF]  

A. de Haan, K. H. L. Gerrits, and C. J. de Ruiter

Counterpoint: The interpolated twitch does not provide a valid measure of the voluntary activation of muscle
J Appl Physiol 107: 355-357, 2009; doi:10.1152/japplphysiol.91220.2008a [Full Text] [PDF]  

Rebuttal from Taylor
J Appl Physiol 107: 357-358, 2009; doi:10.1152/japplphysiol.91220.2008b [Full Text] [PDF]  

Rebuttal from de Haan, Gerrits, and de Ruiter
J Appl Physiol 107: 358-358, 2009; doi:10.1152/japplphysiol.91220.2008c [Full Text] [PDF]  

Janet L. Taylor

Last Word on Point:Counterpoint: The interpolated twitch does/does not provide a valid measure of the voluntary activation of muscle
J Appl Physiol 107: 367-367, 2009; doi:10.1152/japplphysiol.00418.2009 [Full Text] [PDF]  

A. de Haan, K. H. L. Gerrits, and C. J. de Ruiter

Last Word on Point:Counterpoint: The interpolated twitch does/does not provide a valid measure of the voluntary activation of muscle
J Appl Physiol 107: 368-368, 2009; doi:10.1152/japplphysiol.00405.2009 [Full Text] [PDF]  

POINT-COUNTERPOINT COMMENTS

Astrid M. Horstman, Roger M. Enoka, Olivier Girard, Nicolas Babault, Walter Herzog, Sebastien Racinais, Olivier Girard, Jacques Duchateau, David G. Behm, Jan Lexell, Michael Miller, Jennifer M. Jakobi, Stuart A. Binder-Macleod, Ramu Perumal, Li-Wei Chou, Trisha Kesar, Lynn Snyder-Mackler, Simon C. Gandevia, Lisa Griffin, Tamanna Shaikh, Timothy J. Carroll, Andrew G. Cresswell, Kevin G. Keenan, Robert D. Herbert, and Jonathan P. Folland

Comments on Point:Counterpoint: The interpolated twitch does/does not provide a valid measure of the voluntary activation of muscle
J Appl Physiol 107: 359-366, 2009; doi:10.1152/japplphysiol.00362.2009 [Full Text] [PDF]  

LETTERS TO THE EDITOR

G. L. Brengelmann

Steady-state venous return: residue in a recent model analysis of the notion that it is driven by elastic recoil of the venous system
J Appl Physiol 107: 369-369, 2009; doi:10.1152/japplphysiol.00208.2009 [Full Text] [PDF]  

S. Magder

Reply to Brengelmann
J Appl Physiol 107: 370-370, 2009; doi:10.1152/japplphysiol.00375.2009 [Full Text] [PDF]  

Valentina Quaresima and Marco Ferrari

Muscle oxygenation by near-infrared-based tissue oximeters
J Appl Physiol 107: 371-371, 2009; doi:10.1152/japplphysiol.00215.2009 [Full Text] [PDF]  

Andrew M. Jones, Rosemary C. Davies, Leonardo F. Ferreira, Thomas J. Barstow, Shunsaku Koga, and David C. Poole

Reply to Quaresima and Ferrari
J Appl Physiol 107: 372-373, 2009; doi:10.1152/japplphysiol.00314.2009 [Full Text] [PDF]  

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