INVITED EDITORIAL

Virginia M. Miller, Thomas B. Clarkson, S. Mitchell Harman, Eliot A. Brinton, Marcelle Cedars, Rogerio Lobo, JoAnn E. Manson, George R. Merriam, Frederick Naftolin, and Nanette Santoro

Women, hormones, and clinical trials: a beginning, not an end
J Appl Physiol 99: 381-383, 2005; doi:10.1152/japplphysiol.00248.2005 [Full Text] [PDF]  

Rolf D. Hubmayr

Ventilator-induced lung injury without biotrauma?
J Appl Physiol 99: 384-385, 2005; doi:10.1152/japplphysiol.00357.2005 [Full Text] [PDF]  

Steven E. Lipshultz and Tracie L. Miller

Establishing norms for echocardiographic measurements of cardiovascular structures and function in children
J Appl Physiol 99: 386-388, 2005; doi:10.1152/japplphysiol.00167.2005 [Full Text] [PDF]  

INVITED REVIEW

Katrina S. Maluf and Roger M. Enoka

Task failure during fatiguing contractions performed by humans
J Appl Physiol 99: 389-396, 2005; doi:10.1152/japplphysiol.00207.2005 [Abstract] [Full Text] [PDF]  

Martin Flück, Christoph Däpp, Silvia Schmutz, Ernst Wit, and Hans Hoppeler

Transcriptional profiling of tissue plasticity: role of shifts in gene expression and technical limitations
J Appl Physiol 99: 397-413, 2005; doi:10.1152/japplphysiol.00050.2005 [Abstract] [Full Text] [PDF]  

Eva R. Chin

Role of Ca²⁺/calmodulin-dependent kinases in skeletal muscle plasticity
J Appl Physiol 99: 414-423, 2005; doi:10.1152/japplphysiol.00015.2005 [Abstract] [Full Text] [PDF]  

HISTORICAL PERSPECTIVES

John B. West

The physiological challenges of the 1952 Copenhagen poliomyelitis epidemic and a renaissance in clinical respiratory physiology
J Appl Physiol 99: 424-432, 2005; doi:10.1152/japplphysiol.00184.2005 [Abstract] [Full Text] [PDF]  

ARTICLES

Edgardo D'Angelo, Matteo Pecchiari, Patrizia Della Valle, Antonia Koutsoukou, and Joseph Milic-Emili

Effects of mechanical ventilation at low lung volume on respiratory mechanics and nitric oxide exhalation in normal rabbits
J Appl Physiol 99: 433-444, 2005. First published March 10, 2005; doi:10.1152/japplphysiol.01368.2004 [Abstract] [Full Text] [PDF]  

Thierry Sluysmans and Steven D. Colan

Theoretical and empirical derivation of cardiovascular allometric relationships in children
J Appl Physiol 99: 445-457, 2005. First published November 19, 2004; doi:10.1152/japplphysiol.01144.2004 [Abstract] [Full Text] [PDF]  

Shailesh Naire and Oliver E. Jensen

Epithelial cell deformation during surfactant-mediated airway reopening: a theoretical model
J Appl Physiol 99: 458-471, 2005. First published March 31, 2005; doi:10.1152/japplphysiol.00796.2004 [Abstract] [Full Text] [PDF] [Supplemental Appendix]  

Otto A. Sanchez, LeAnn M. Snow, Dawn A. Lowe, Robert C. Serfass, and LaDora V. Thompson

Effects of endurance exercise-training on single-fiber contractile properties of insulin-treated streptozotocin-induced diabetic rats
J Appl Physiol 99: 472-478, 2005. First published April 14, 2005; doi:10.1152/japplphysiol.01233.2004 [Abstract] [Full Text] [PDF]  

Andrés J. Calderón, J. Brian Fowlkes, and Joseph L. Bull

Bubble splitting in bifurcating tubes: a model study of cardiovascular gas emboli transport
J Appl Physiol 99: 479-487, 2005. First published March 24, 2005; doi:10.1152/japplphysiol.00656.2004 [Abstract] [Full Text] [PDF]  

Krzysztof Wroblewski, Simon Spalthoff, Un-Jin Zimmerman, Robert L. Post, Joseph W. Sanger, and Robert E. Forster

The role of carbonic anhydrase in the recovery of skeletal muscle from anoxia
J Appl Physiol 99: 488-498, 2005. First published March 31, 2005; doi:10.1152/japplphysiol.01409.2004 [Abstract] [Full Text] [PDF]  

Ralph Beneke, Matthias Hütler, Marcus Jung, and Renate M. Leithäuser

Modeling the blood lactate kinetics at maximal short-term exercise conditions in children, adolescents, and adults
J Appl Physiol 99: 499-504, 2005; doi:10.1152/japplphysiol.00062.2005 [Abstract] [Full Text] [PDF]  

Kevin E. Eklund, K. Sue Hageman, David C. Poole, and Timothy I. Musch

Impact of aging on muscle blood flow in chronic heart failure
J Appl Physiol 99: 505-514, 2005. First published March 31, 2005; doi:10.1152/japplphysiol.00896.2004 [Abstract] [Full Text] [PDF]  

Catherine O'Brien, Beau J. Freund, Andrew J. Young, and Michael N. Sawka

Glycerol hyperhydration: physiological responses during cold-air exposure
J Appl Physiol 99: 515-521, 2005. First published April 7, 2005; doi:10.1152/japplphysiol.00176.2005 [Abstract] [Full Text] [PDF]  

Niels P. Riksen, Egidia E. M. van Ginneken, Petra H. H. van den Broek, Paul Smits, and Gerard A. Rongen

In vivo evidence against a role for adenosine in the exercise pressor reflex in humans
J Appl Physiol 99: 522-527, 2005. First published April 7, 2005; doi:10.1152/japplphysiol.00108.2005 [Abstract] [Full Text] [PDF]  

Li Chen, Xing-Hai Yao, and B. L. G. Nyomba

In vivo insulin signaling through PI3-kinase is impaired in skeletal muscle of adult rat offspring exposed to ethanol in utero
J Appl Physiol 99: 528-534, 2005. First published March 24, 2005; doi:10.1152/japplphysiol.01098.2004 [Abstract] [Full Text] [PDF]  

Jarna C. Hannukainen, Urho M. Kujala, Jyri Toikka, Olli J. Heinonen, Jukka Kapanen, Tero Vahlberg, Jaakko Kaprio, and Kari K. Kalliokoski

Cardiac structure and function in monozygotic twin pairs discordant for physical fitness
J Appl Physiol 99: 535-541, 2005. First published April 7, 2005; doi:10.1152/japplphysiol.00107.2005 [Abstract] [Full Text] [PDF]  

Y. Mounier, V. Montel, F. Picquet, L. Stevens, B. Bastide, and M. Falempin

Dual effect of deafferentation on contractile characteristics and sarcoplasmic reticulum properties in rat soleus fibers
J Appl Physiol 99: 542-548, 2005. First published March 24, 2005; doi:10.1152/japplphysiol.00757.2004 [Abstract] [Full Text] [PDF]  

Liam S. Doherty, Philip Nolan, and Walter T. McNicholas

Effects of topical anesthesia on upper airway resistance during wake-sleep transitions
J Appl Physiol 99: 549-555, 2005. First published March 24, 2005; doi:10.1152/japplphysiol.01221.2004 [Abstract] [Full Text] [PDF]  

David B. Pearse, Robert M. Searcy, Wayne Mitzner, Solbert Permutt, and J. T. Sylvester

Effects of tidal volume and respiratory frequency on lung lymph flow
J Appl Physiol 99: 556-563, 2005. First published March 24, 2005; doi:10.1152/japplphysiol.00254.2005 [Abstract] [Full Text] [PDF]  

Priscilla M. Clarkson, Eric P. Hoffman, Edward Zambraski, Heather Gordish-Dressman, Amy Kearns, Monica Hubal, Brennan Harmon, and Joseph M. Devaney

ACTN3 and MLCK genotype associations with exertional muscle damage
J Appl Physiol 99: 564-569, 2005. First published April 7, 2005; doi:10.1152/japplphysiol.00130.2005 [Abstract] [Full Text] [PDF]  

Paul Jarle Mork and Rolf H. Westgaard

Long-term electromyographic activity in upper trapezius and low back muscles of women with moderate physical activity
J Appl Physiol 99: 570-578, 2005. First published April 7, 2005; doi:10.1152/japplphysiol.00198.2005 [Abstract] [Full Text] [PDF]  

C. J. de Ruiter, M. D. de Boer, M. Spanjaard, and A. de Haan

Knee angle-dependent oxygen consumption during isometric contractions of the knee extensors determined with near-infrared spectroscopy
J Appl Physiol 99: 579-586, 2005. First published March 17, 2005; doi:10.1152/japplphysiol.01420.2004 [Abstract] [Full Text] [PDF]  

Shizue Masuki, Frank A. Dinenno, Michael J. Joyner, and John H. Eisenach

Selective ₂-adrenergic properties of dexmedetomidine over clonidine in the human forearm
J Appl Physiol 99: 587-592, 2005. First published March 31, 2005; doi:10.1152/japplphysiol.00147.2005 [Abstract] [Full Text] [PDF]  

Timothy A. Butterfield and Walter Herzog

Quantification of muscle fiber strain during in vivo repetitive stretch-shortening cycles
J Appl Physiol 99: 593-602, 2005. First published March 24, 2005; doi:10.1152/japplphysiol.01128.2004 [Abstract] [Full Text] [PDF]  

Masaki Ishikawa, Paavo V. Komi, Michael J. Grey, Vesa Lepola, and Gert-Peter Bruggemann

Muscle-tendon interaction and elastic energy usage in human walking
J Appl Physiol 99: 603-608, 2005. First published April 21, 2005; doi:10.1152/japplphysiol.00189.2005 [Abstract] [Full Text] [PDF]  

Shelly D. Weise, Peter W. Grandjean, J. James Rohack, John W. Womack, and Stephen F. Crouse

Acute changes in blood lipids and enzymes in postmenopausal women after exercise
J Appl Physiol 99: 609-615, 2005. First published March 17, 2005; doi:10.1152/japplphysiol.01354.2004 [Abstract] [Full Text] [PDF]  

Erkan Tarhan, Mehmet Coskun, Ozcan Cakmak, Hüseyin Çelik, and Mehmet Cankurtaran

Acoustic rhinometry in humans: accuracy of nasal passage area estimates, and ability to quantify paranasal sinus volume and ostium size
J Appl Physiol 99: 616-623, 2005. First published March 31, 2005; doi:10.1152/japplphysiol.00106.2005 [Abstract] [Full Text] [PDF]  

Shannon L. Seurynck, Nathan J. Brown, Cindy W. Wu, Kevin W. Germino, Ellen K. Kohlmeir, Edward P. Ingenito, Matthew R. Glucksberg, Annelise E. Barron, and Mark Johnson

Optical monitoring of bubble size and shape in a pulsating bubble surfactometer
J Appl Physiol 99: 624-633, 2005. First published March 24, 2005; doi:10.1152/japplphysiol.00748.2004 [Abstract] [Full Text] [PDF]  

Linhong Deng, Nigel J. Fairbank, Darren J. Cole, Jeffrey J. Fredberg, and Geoffrey N. Maksym

Airway smooth muscle tone modulates mechanically induced cytoskeletal stiffening and remodeling
J Appl Physiol 99: 634-641, 2005. First published April 21, 2005; doi:10.1152/japplphysiol.00025.2005 [Abstract] [Full Text] [PDF]  

Evelyne Gozal, Zahoor A. Shah, Jean-Marc Pequignot, Jacqueline Pequignot, Leroy R. Sachleben, Maria F. Czyzyk-Krzeska, Richard C. Li, Shang-Z. Guo, and David Gozal

Tyrosine hydroxylase expression and activity in the rat brain: differential regulation after long-term intermittent or sustained hypoxia
J Appl Physiol 99: 642-649, 2005. First published April 7, 2005; doi:10.1152/japplphysiol.00880.2004 [Abstract] [Full Text] [PDF]  

G. Tusman, M. Areta, C. Climente, R. Plit, F. Suarez-Sipmann, M. J. Rodríguez-Nieto, G. Peces-Barba, E. Turchetto, and S. H. Böhm

Effect of pulmonary perfusion on the slopes of single-breath test of CO₂
J Appl Physiol 99: 650-655, 2005. First published March 31, 2005; doi:10.1152/japplphysiol.01115.2004 [Abstract] [Full Text] [PDF]  

D. J. Barr, H. J. Green, D. S. Lounsbury, J. W. E. Rush, and J. Ouyang

Na⁺-K⁺-ATPase properties in rat heart and skeletal muscle 3 mo after coronary artery ligation
J Appl Physiol 99: 656-664, 2005. First published April 7, 2005; doi:10.1152/japplphysiol.00343.2004 [Abstract] [Full Text] [PDF]  

Tetsuro Muraoka, Tadashi Muramatsu, Tetsuo Fukunaga, and Hiroaki Kanehisa

Elastic properties of human Achilles tendon are correlated to muscle strength
J Appl Physiol 99: 665-669, 2005. First published March 24, 2005; doi:10.1152/japplphysiol.00624.2004 [Abstract] [Full Text] [PDF]  

Candice D. Fike, Yongmei Zhang, and Mark R. Kaplowitz

Thromboxane inhibition reduces an early stage of chronic hypoxia-induced pulmonary hypertension in piglets
J Appl Physiol 99: 670-676, 2005. First published March 31, 2005; doi:10.1152/japplphysiol.01337.2004 [Abstract] [Full Text] [PDF]  

Z. Xue, L. Zhang, R. Ramchandani, Y. Liu, V. B. Antony, S. J. Gunst, and R. S. Tepper

Respiratory system responsiveness in rabbits in vivo is reduced by prolonged continuous positive airway pressure
J Appl Physiol 99: 677-682, 2005. First published April 7, 2005; doi:10.1152/japplphysiol.00165.2005 [Abstract] [Full Text] [PDF]  

Nicole D. Paterson, John M. Kowalchuk, and Donald H. Paterson

Kinetics of V^.0₂ and femoral artery blood flow during heavy-intensity, knee-extension exercise
J Appl Physiol 99: 683-690, 2005. First published April 7, 2005; doi:10.1152/japplphysiol.00707.2004 [Abstract] [Full Text] [PDF]  

Thomas E. Dick, Roger Shannon, Bruce G. Lindsey, Sarah C. Nuding, Lauren S. Segers, David M. Baekey, and Kendall F. Morris

Arterial pulse modulated activity is expressed in respiratory neural output
J Appl Physiol 99: 691-698, 2005. First published March 10, 2005; doi:10.1152/japplphysiol.01124.2004 [Abstract] [Full Text] [PDF]  

C. H. E. Imray, S. D. Myers, K. T. S. Pattinson, A. R. Bradwell, C. W. Chan, S. Harris, P. Collins, A. D. Wright the Birmingham Medical Research Expeditionary Society

Effect of exercise on cerebral perfusion in humans at high altitude
J Appl Physiol 99: 699-706, 2005. First published May 26, 2005; doi:10.1152/japplphysiol.00973.2004 [Abstract] [Full Text] [PDF]  

Shiou-Liang Wee, Clyde Williams, Kostas Tsintzas, and Leslie Boobis

Ingestion of a high-glycemic index meal increases muscle glycogen storage at rest but augments its utilization during subsequent exercise
J Appl Physiol 99: 707-714, 2005. First published April 14, 2005; doi:10.1152/japplphysiol.01261.2004 [Abstract] [Full Text] [PDF]  

Theodore F. Towse, Jill M. Slade, and Ronald A. Meyer

Effect of physical activity on MRI-measured blood oxygen level-dependent transients in skeletal muscle after brief contractions
J Appl Physiol 99: 715-722, 2005. First published March 31, 2005; doi:10.1152/japplphysiol.00272.2005 [Abstract] [Full Text] [PDF]  

Gilman B. Allen, Lucio A. Pavone, Joseph D. DiRocco, Jason H. T. Bates, and Gary F. Nieman

Pulmonary impedance and alveolar instability during injurious ventilation in rats
J Appl Physiol 99: 723-730, 2005. First published April 14, 2005; doi:10.1152/japplphysiol.01339.2004 [Abstract] [Full Text] [PDF]  

Kelly S. Burrowes, Peter J. Hunter, and Merryn H. Tawhai

Anatomically based finite element models of the human pulmonary arterial and venous trees including supernumerary vessels
J Appl Physiol 99: 731-738, 2005. First published March 31, 2005; doi:10.1152/japplphysiol.01033.2004 [Abstract] [Full Text] [PDF]  

Antonios Kyparos, Daniel L. Feeback, Charles S. Layne, Daniel A. Martinez, and Mark S. F. Clarke

Mechanical stimulation of the plantar foot surface attenuates soleus muscle atrophy induced by hindlimb unloading in rats
J Appl Physiol 99: 739-746, 2005. First published April 7, 2005; doi:10.1152/japplphysiol.00771.2004 [Abstract] [Full Text] [PDF]  

Ercheng Zhu, Catherine S. H. Sassoon, Renee Nelson, H. Tony Pham, Lei Zhu, Michael J. Baker, and Vincent J. Caiozzo

Early effects of mechanical ventilation on isotonic contractile properties and MAF-box gene expression in the diaphragm
J Appl Physiol 99: 747-756, 2005. First published April 14, 2005; doi:10.1152/japplphysiol.00126.2005 [Abstract] [Full Text] [PDF]  

HIGHLIGHTED TOPICS

Jason R. Berggren, Matthew W. Hulver, and Joseph A. Houmard

Invited Review  Fat as an endocrine organ: influence of exercise
J Appl Physiol 99: 757-764, 2005; doi:10.1152/japplphysiol.00134.2005 [Abstract] [Full Text] [PDF]  

James O. Hill and Holly R. Wyatt

Invited Review  Role of physical activity in preventing and treating obesity
J Appl Physiol 99: 765-770, 2005; doi:10.1152/japplphysiol.00137.2005 [Abstract] [Full Text] [PDF]  

POINT-COUNTERPOINT COMMENTS

Michael E. Tschakovsky

The muscle pump debate: selective literature representations.
J Appl Physiol 99: 771-771, 2005; doi:10.1152/japplphysiol.00574.2005 [Full Text] [PDF]  

D. Walter Wray and Russell S. Richardson

The muscle pump is/is not an important determinant of muscle blood flow during exercise.
J Appl Physiol 99: 772-772, 2005; doi:10.1152/japplphysiol.00499.2005 [Full Text] [PDF]  

Carl F. Rothe

The muscle pump indeed raises muscle blood flow during locomotion.
J Appl Physiol 99: 773-773, 2005; doi:10.1152/japplphysiol.00602.2005 [Full Text] [PDF]  

M. Harold Laughlin

The muscle pump, What question do we want to answer?
J Appl Physiol 99: 774-774, 2005; doi:10.1152/japplphysiol.00578.2005 [Full Text] [PDF]  

Thomas J Barstow, Barbara J Lutjemeier, and Leonardo F Ferreira

Kinetics of restoration of arteriolar tone after exercise.
J Appl Physiol 99: 775-775, 2005; doi:10.1152/japplphysiol.00603.2005 [Full Text] [PDF]  

Jordan D. Miller

Evidence of venous suction, but from where?
J Appl Physiol 99: 776-776, 2005; doi:10.1152/japplphysiol.00593.2005 [Full Text] [PDF]  

S. Magder

Muscle contractions increase exercise hyperemia by being permissive for high flows.
J Appl Physiol 99: 777-777, 2005; doi:10.1152/japplphysiol.00611.2005 [Full Text] [PDF]  

Vladimir S Panchev, Adelina V Suvandjieva, and Marieta V Pancheva

The muscle pump is not an important determinant of muscle blood flow during exercise.
J Appl Physiol 99: 778-778, 2005; doi:10.1152/japplphysiol.00600.2005 [Full Text] [PDF]  

LETTERS TO THE EDITOR

Eric T. Poehlman

Retraction of Poehlman et al. Journal of Applied Physiology 76: 2281–2287, 1994
J Appl Physiol 99: 779-779, 2005; doi:10.1152/japplphysiol.00519.2005 [Abstract] [Full Text] [PDF]  

James R. Matthie

Second generation mixture theory equation for estimating intracellular water using bioimpedance spectroscopy
J Appl Physiol 99: 780-781, 2005; doi:10.1152/japplphysiol.00145.2005 [Full Text] [PDF]  

CORRIGENDA

CORRIGENDUM
J Appl Physiol 99: 782-782, 2005; doi:10.1152/japplphysiol.00557.2005 [Full Text] [PDF]  

RETRACTION

Retraction
J Appl Physiol 99: 783-783, 2005; doi:10.1152/japplphysiol.00521.2005 [Full Text] [PDF]  

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