INVITED EDITORIAL

S. C. Gandevia and J. L. Taylor

Supraspinal fatigue: the effects of caffeine on human muscle performance
J Appl Physiol 100: 1749-1750, 2006; doi:10.1152/japplphysiol.00121.2006 [Full Text] [PDF]  

John A. Hawley and Fiona J. Spargo

It's all in the genes, so pick your parents wisely
J Appl Physiol 100: 1751-1752, 2006; doi:10.1152/japplphysiol.00150.2006 [Full Text] [PDF]  

Michael B. Reid

Waste not, weak not?
J Appl Physiol 100: 1753-1754, 2006; doi:10.1152/japplphysiol.00190.2005 [Full Text] [PDF]  

Frank Booth

The many flavors of IGF-I
J Appl Physiol 100: 1755-1756, 2006; doi:10.1152/japplphysiol.00205.2006 [Full Text] [PDF]  

ARTICLES

J. M. Kalmar and E. Cafarelli

Central excitability does not limit postfatigue voluntary activation of quadriceps femoris
J Appl Physiol 100: 1757-1764, 2006. First published January 19, 2006; doi:10.1152/japplphysiol.01347.2005 [Abstract] [Full Text] [PDF]  

B. Walsh, R. B. Hooks, J. E. Hornyak, L. G. Koch, S. L. Britton, and M. C. Hogan

Enhanced mitochondrial sensitivity to creatine in rats bred for high aerobic capacity
J Appl Physiol 100: 1765-1769, 2006. First published January 19, 2006; doi:10.1152/japplphysiol.01533.2005 [Abstract] [Full Text] [PDF]  

Gerald S. Supinski and Leigh A. Callahan

Caspase activation contributes to endotoxin-induced diaphragm weakness
J Appl Physiol 100: 1770-1777, 2006. First published February 16, 2006; doi:10.1152/japplphysiol.01288.2005 [Abstract] [Full Text] [PDF]  

Elisabeth R. Barton

Viral expression of insulin-like growth factor-I isoforms promotes different responses in skeletal muscle
J Appl Physiol 100: 1778-1784, 2006. First published January 26, 2006; doi:10.1152/japplphysiol.01405.2005 [Abstract] [Full Text] [PDF]  

Hong Guo, Nancy Tierney, Frederic Schaller, Peter B. Raven, Scott A. Smith, and Xiangrong Shi

Cerebral autoregulation is preserved during orthostatic stress superimposed with systemic hypotension
J Appl Physiol 100: 1785-1792, 2006. First published January 19, 2006; doi:10.1152/japplphysiol.00690.2005 [Abstract] [Full Text] [PDF]  

Masahiro Shibata, Kairong Qin, Shigeru Ichioka, and Akira Kamiya

Vascular wall energetics in arterioles during nitric oxide-dependent and -independent vasodilation
J Appl Physiol 100: 1793-1798, 2006. First published February 23, 2006; doi:10.1152/japplphysiol.01632.2005 [Abstract] [Full Text] [PDF]  

Michael I. Lewis, Sue C. Bodine, Nader Kamangar, Xuan Xu, Xiaoyu Da, and Mario Fournier

Effect of severe short-term malnutrition on diaphragm muscle signal transduction pathways influencing protein turnover
J Appl Physiol 100: 1799-1806, 2006. First published February 16, 2006; doi:10.1152/japplphysiol.01233.2005 [Abstract] [Full Text] [PDF]  

Sandeep Sood, Eric Raddatz, Xia Liu, Hattie Liu, and Richard L. Horner

Inhibition of serotonergic medullary raphe obscurus neurons suppresses genioglossus and diaphragm activities in anesthetized but not conscious rats
J Appl Physiol 100: 1807-1821, 2006. First published February 16, 2006; doi:10.1152/japplphysiol.01508.2005 [Abstract] [Full Text] [PDF]  

Marina Mourtzakis, Bengt Saltin, Terry Graham, and Henriette Pilegaard

Carbohydrate metabolism during prolonged exercise and recovery: interactions between pyruvate dehydrogenase, fatty acids, and amino acids
J Appl Physiol 100: 1822-1830, 2006. First published January 19, 2006; doi:10.1152/japplphysiol.00571.2005 [Abstract] [Full Text] [PDF]  

Henry Stämpfli, Michael Taylor, Carl McNicoll, Ady Y. Gancz, and Peter D. Constable

Experimental determination of net protein charge, [A]_tot, and K_a of nonvolatile buffers in bird plasma
J Appl Physiol 100: 1831-1836, 2006. First published January 19, 2006; doi:10.1152/japplphysiol.01367.2005 [Abstract] [Full Text] [PDF]  

P. J. Blijham, H. J. ter Laak, H. J. Schelhaas, B. G. M. van Engelen, D. F. Stegeman, and M. J. Zwarts

Relation between muscle fiber conduction velocity and fiber size in neuromuscular disorders
J Appl Physiol 100: 1837-1841, 2006. First published January 19, 2006; doi:10.1152/japplphysiol.01009.2005 [Abstract] [Full Text] [PDF]  

Stephanie N. Mateev, Rhonda Mouser, David A. Young, Robert P. Mecham, and Lorna G. Moore

Chronic hypoxia augments uterine artery distensibility and alters the circumferential wall stress-strain relationship during pregnancy
J Appl Physiol 100: 1842-1850, 2006; doi:10.1152/japplphysiol.00618.2005 [Abstract] [Full Text] [PDF]  

Keith Tolfrey, Alan Barker, Jeanette M. Thom, Christopher I. Morse, Marco V. Narici, and Alan M. Batterham

Scaling of maximal oxygen uptake by lower leg muscle volume in boys and men
J Appl Physiol 100: 1851-1856, 2006. First published February 16, 2006; doi:10.1152/japplphysiol.01213.2005 [Abstract] [Full Text] [PDF]  

James M. Williams, Charles R. White, Melody M. Chang, Elisha R. Injeti, Lubo Zhang, and William J. Pearce

Chronic hypoxic decreases in soluble guanylate cyclase protein and enzyme activity are age dependent in fetal and adult ovine carotid arteries
J Appl Physiol 100: 1857-1866, 2006. First published February 9, 2006; doi:10.1152/japplphysiol.00662.2005 [Abstract] [Full Text] [PDF]  

Sergiu Fediuc, Jonathan E. Campbell, and Michael C. Riddell

Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats
J Appl Physiol 100: 1867-1875, 2006. First published January 26, 2006; doi:10.1152/japplphysiol.01416.2005 [Abstract] [Full Text] [PDF]  

Mandy T. Woolstenhulme, Robert K. Conlee, Micah J. Drummond, Aaron W. Stites, and Allen C. Parcell

Temporal response of desmin and dystrophin proteins to progressive resistance exercise in human skeletal muscle
J Appl Physiol 100: 1876-1882, 2006. First published January 26, 2006; doi:10.1152/japplphysiol.01592.2005 [Abstract] [Full Text] [PDF]  

Tracy J. Horton, Gary K. Grunwald, Jennifer Lavely, and W. Troy Donahoo

Glucose kinetics differ between women and men, during and after exercise
J Appl Physiol 100: 1883-1894, 2006; doi:10.1152/japplphysiol.01431.2005 [Abstract] [Full Text] [PDF]  

Michael K. Stickland, Robert C. Welsh, Stewart R. Petersen, John V. Tyberg, William D. Anderson, Richard L. Jones, Dylan A. Taylor, Marcel Bouffard, and Mark J. Haykowsky

Does fitness level modulate the cardiovascular hemodynamic response to exercise?
J Appl Physiol 100: 1895-1901, 2006. First published February 23, 2006; doi:10.1152/japplphysiol.01485.2005 [Abstract] [Full Text] [PDF]  

Sergio Montero, Herón Mendoza, Victoria Valles, Mónica Lemus, Ramón Alvarez-Buylla, and Elena R. de Alvarez-Buylla

Arginine-vasopressin mediates central and peripheral glucose regulation in response to carotid body receptor stimulation with Na-cyanide
J Appl Physiol 100: 1902-1909, 2006. First published February 23, 2006; doi:10.1152/japplphysiol.01414.2005 [Abstract] [Full Text] [PDF]  

Michael K. Stickland, Robert C. Welsh, Mark J. Haykowsky, Stewart R. Petersen, William D. Anderson, Dylan A. Taylor, Marcel Bouffard, and Richard L. Jones

Effect of acute increases in pulmonary vascular pressures on exercise pulmonary gas exchange
J Appl Physiol 100: 1910-1917, 2006. First published March 2, 2006; doi:10.1152/japplphysiol.01484.2005 [Abstract] [Full Text] [PDF]  

Dale R. Bergren

Prostaglandin involvement in lung C-fiber activation by substance P in guinea pigs
J Appl Physiol 100: 1918-1927, 2006. First published February 2, 2006; doi:10.1152/japplphysiol.01276.2005 [Abstract] [Full Text] [PDF]  

Kevin G. Keenan, Dario Farina, Roberto Merletti, and Roger M. Enoka

Amplitude cancellation reduces the size of motor unit potentials averaged from the surface EMG
J Appl Physiol 100: 1928-1937, 2006. First published January 5, 2006; doi:10.1152/japplphysiol.01282.2005 [Abstract] [Full Text] [PDF]  

Jon Peter Wehrlin, Peter Zuest, Jostein Hallén, and Bernard Marti

Live high-train low for 24 days increases hemoglobin mass and red cell volume in elite endurance athletes
J Appl Physiol 100: 1938-1945, 2006. First published February 23, 2006; doi:10.1152/japplphysiol.01284.2005 [Abstract] [Full Text] [PDF]  

A. Stekelenburg, C. W. J. Oomens, G. J. Strijkers, K. Nicolay, and D. L. Bader

Compression-induced deep tissue injury examined with magnetic resonance imaging and histology
J Appl Physiol 100: 1946-1954, 2006. First published February 16, 2006; doi:10.1152/japplphysiol.00889.2005 [Abstract] [Full Text] [PDF]  

Arundhathi Jeyabalan, Laurie J. Kerchner, Michelle C. Fisher, Jonathan T. McGuane, Ketah D. Doty, and Kirk P. Conrad

Matrix metalloproteinase-2 activity, protein, mRNA, and tissue inhibitors in small arteries from pregnant and relaxin-treated nonpregnant rats
J Appl Physiol 100: 1955-1963, 2006. First published February 16, 2006; doi:10.1152/japplphysiol.01330.2005 [Abstract] [Full Text] [PDF]  

Sam Bayat, Liisa Porra, Heikki Suhonen, Christian Nemoz, Pekka Suortti, and Anssi R. A. Sovijärvi

Differences in the time course of proximal and distal airway response to inhaled histamine studied by synchrotron radiation CT
J Appl Physiol 100: 1964-1973, 2006. First published February 9, 2006; doi:10.1152/japplphysiol.00594.2005 [Abstract] [Full Text] [PDF]  

C. J. Lai, C. C. H. Yang, Y. Y. Hsu, Y. N. Lin, and T. B. J. Kuo

Enhanced sympathetic outflow and decreased baroreflex sensitivity are associated with intermittent hypoxia-induced systemic hypertension in conscious rats
J Appl Physiol 100: 1974-1982, 2006. First published February 16, 2006; doi:10.1152/japplphysiol.01051.2005 [Abstract] [Full Text] [PDF]  

Muyao Li, Margaret A. Vizzard, Diane M. Jaworski, and Richard A. Galbraith

The weight loss elicited by cobalt protoporphyrin is related to decreased activity of nitric oxide synthase in the hypothalamus
J Appl Physiol 100: 1983-1991, 2006. First published February 9, 2006; doi:10.1152/japplphysiol.01169.2005 [Abstract] [Full Text] [PDF]  

Hagit Schwimmer, Luba Eli-Berchoer, and Michal Horowitz

Acclimatory-phase specificity of gene expression during the course of heat acclimation and superimposed hypohydration in the rat hypothalamus
J Appl Physiol 100: 1992-2003, 2006. First published February 9, 2006; doi:10.1152/japplphysiol.00850.2005 [Abstract] [Full Text] [PDF] [Supplement Table]  

Hae-Dong Lee, Taija Finni, John A. Hodgson, Alex M. Lai, V. Reggie Edgerton, and Shantanu Sinha

Soleus aponeurosis strain distribution following chronic unloading in humans: an in vivo MR phase-contrast study
J Appl Physiol 100: 2004-2011, 2006. First published January 19, 2006; doi:10.1152/japplphysiol.01085.2005 [Abstract] [Full Text] [PDF]  

J. M. McClung, J. M. Davis, M. A. Wilson, E. C. Goldsmith, and J. A. Carson

Estrogen status and skeletal muscle recovery from disuse atrophy
J Appl Physiol 100: 2012-2023, 2006. First published February 23, 2006; doi:10.1152/japplphysiol.01583.2005 [Abstract] [Full Text] [PDF]  

J. C. Bruusgaard, K. Liestøl, and K. Gundersen

Distribution of myonuclei and microtubules in live muscle fibers of young, middle-aged, and old mice
J Appl Physiol 100: 2024-2030, 2006. First published February 23, 2006; doi:10.1152/japplphysiol.00913.2005 [Abstract] [Full Text] [PDF]  

Andrew R. Hsu, Kimberly E. Barnholt, Nicolas K. Grundmann, Joseph H. Lin, Stewart W. McCallum, and Anne L. Friedlander

Sildenafil improves cardiac output and exercise performance during acute hypoxia, but not normoxia
J Appl Physiol 100: 2031-2040, 2006. First published February 2, 2006; doi:10.1152/japplphysiol.00806.2005 [Abstract] [Full Text] [PDF]  

Kirsten A. Burgomaster, George J. F. Heigenhauser, and Martin J. Gibala

Effect of short-term sprint interval training on human skeletal muscle carbohydrate metabolism during exercise and time-trial performance
J Appl Physiol 100: 2041-2047, 2006. First published February 9, 2006; doi:10.1152/japplphysiol.01220.2005 [Abstract] [Full Text] [PDF]  

Gladys L. Onambele, Marco V. Narici, and Constantinos N. Maganaris

Calf muscle-tendon properties and postural balance in old age
J Appl Physiol 100: 2048-2056, 2006. First published February 2, 2006; doi:10.1152/japplphysiol.01442.2005 [Abstract] [Full Text] [PDF]  

HIGHLIGHTED TOPICS

Avijit Datta and Michael Tipton

Respiratory responses to cold water immersion: neural pathways, interactions, and clinical consequences awake and asleep
J Appl Physiol 100: 2057-2064, 2006; doi:10.1152/japplphysiol.01201.2005 [Abstract] [Full Text] [PDF]  

Igor B. Mekjavic and Ola Eiken

Contribution of thermal and nonthermal factors to the regulation of body temperature in humans
J Appl Physiol 100: 2065-2072, 2006. First published January 12, 2006; doi:10.1152/japplphysiol.01118.2005 [Abstract] [Full Text] [PDF]  

W. C. Lee, H. C. Wen, C. P. Chang, M. Y. Chen, and M. T. Lin

Heat shock protein 72 overexpression protects against hyperthermia, circulatory shock, and cerebral ischemia during heatstroke
J Appl Physiol 100: 2073-2082, 2006. First published April 20, 2006; doi:10.1152/japplphysiol.01433.2005 [Abstract] [Full Text] [PDF]  

Guy E. Alvarez, Kun Zhao, Wojciech A. Kosiba, and John M. Johnson

Relative roles of local and reflex components in cutaneous vasoconstriction during skin cooling in humans
J Appl Physiol 100: 2083-2088, 2006. First published February 16, 2006; doi:10.1152/japplphysiol.01265.2005 [Abstract] [Full Text] [PDF]  

F. M. Faraci, M. L. Modrick, C. M. Lynch, L. A. Didion, P. E. Fegan, and S. P. Didion

Selective cerebral vascular dysfunction in Mn-SOD-deficient mice
J Appl Physiol 100: 2089-2093, 2006. First published March 2, 2006; doi:10.1152/japplphysiol.00939.2005 [Abstract] [Full Text] [PDF]  

POINT-COUNTERPOINT

Hiroshi Onimaru, Ikuo Homma, Jack L. Feldman, and Wiktor A. Janczewski

Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Bötzinger complex (preBötC) is the primary site of respiratory rhythm generation in the mammal
J Appl Physiol 100: 2094-2098, 2006. First published February 2, 2006; doi:10.1152/japplphysiol.00119.2006 [Full Text] [PDF]  

POINT-COUNTERPOINT COMMENTS

Philippe Connes, Ozlem Yalcin, Oguz Baskurt, Jean-Frédéric Brun, and Max Hardeman

In health and in a normoxic environment, O_{2 max} is/is not limited primarily by cardiac output and locomotor muscle blood flow
J Appl Physiol 100: 2099-2099, 2006; doi:10.1152/japplphysiol.00279.2006 [Full Text] [PDF]  

Michael Ivan Lindinger, George A. Brooks, Gregory C. Henderson, Takeshi Hashimoto, Tamara Mau, Jill A. Fattor, Michael A. Horning, Raja Hussien, Hyung-Sook Cho, Nastaran Faghihnia, Zinta Zarins, L. Bruce Gladden, Michael C. Hogan, John Vissing, and Russell Tupling

Lactic acid accumulation is an advantage/disadvantage during muscle activity
J Appl Physiol 100: 2100-2102, 2006; doi:10.1152/japplphysiol.00213.2006 [Full Text] [PDF]  

Hubert V. Forster, Peter M. Lalley, J. Greer, Eugene E. Nattie, Aihua Li, Christopher A. Del Negro, Paul A. Gray, Mathias Dutschmann, Ilya A. Rybak, Thomas E. Dick, Stephen M. Johnson, Michael S. Hedrick, Gregory D. Funk, Konstantinon Vasilakos, Richard J. A. Wilson, Klaus Ballanyi, and Nicholas M. Mellen

The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal
J Appl Physiol 100: 2103-2108, 2006; doi:10.1152/japplphysiol.00351.2006 [Full Text] [PDF]  

LETTERS TO THE EDITOR

L. Bruce Gladden and K. M. Baldwin

Letter To The Editor
J Appl Physiol 100: 2109-2110, 2006; doi:10.1152/japplphysiol.00163.2006 [Full Text] [PDF]  

CORRIGENDA

Corrigendum
J Appl Physiol 100: 2111-2111, 2006; doi:10.1152/japplphysiol.00354.2006 [Full Text] [PDF]  

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