Cardiovascular disease is the major cause of death worldwide; therefore, it is important to understand the natural history of the pathophysiologic process and develop strategies to halt its progression. Thus, this study investigated the protective effect of aerobic training on pathophysiological mechanisms involved in subclinical cardiometabolic alterations in a model with constant exposure to a prejudicial agent. Male Wistar rats were divided into Control group (C), which received drinking water, Fructose group (F), which was fed 10% fructose in drinking water for 10 weeks; Control Training group (CT) and Fructose Training group (FT), in which moderate aerobic training was added in the last 8 weeks of the study. Insulin, triacylglycerol and isoprostane were higher and superoxide dismutase (SOD) was lower in the F group. There was no difference in thoracic aorta histology, but it was seen a decreased vascularization in F group, avoided by training in left ventricle. Regarding vascular function, the F group exhibited increased vasoconstrictory reactivity to phenylephrine. The F group presented impaired vasodilation to acetylcholine. Regarding endothelial nitric oxide synthase (eNOS), the F group presented a lower expression, and phosphorylated eNOS was higher in the trained groups than in their respective control groups. This same pattern was observed for nitric oxide (NO) bioavailability, antioxidants protein expression in aorta, left ventricle and muscle (catalase, SOD and glutathione peroxidase), serum SOD activity and muscle mass. These results suggest that exercise training enhanced the antioxidant pathway and as consequence the eNOS pathway, preventing an impairment in vascular vasodilatory capacity.
- cardiovascular disease
- antioxidant enzymes
- Copyright © 2015, Journal of Applied Physiology