Hyperglycemia, commonly present after a meal, causes transient impairment in endothelial function. We examined whether increases in blood flow (BF) protect against the hyperglycemia-mediated decrease in endothelial function in healthy subjects and patients with type 2 diabetes mellitus (T2DM). Ten healthy subjects and 10 age- and sex-matched T2DM patients underwent simultaneous bilateral assessment of brachial artery endothelial function by means of flow-mediated dilation (FMD), using high-resolution echo-Doppler. FMD was examined before and 60, 120 and 150 minutes after a 75-gr oral glucose challenge. We unilaterally manipulated BF by heating one arm between minute 30 and 60. Oral glucose administration caused a statistically significant, transient increase in blood glucose in both groups (P<0.001). Forearm skin temperature, brachial artery BF and shear rate significantly increased in the heated arm (P<0.001), and to a greater extent compared to the non-heated arm in both groups (interaction-effect, P<0.001). The glucose load caused a transient decrease in FMD% (P<0.05), whilst heating significantly prevented the decline (interaction-effect: P<0.01). Also when correcting for changes in diameter and shear rate, we found that the hyperglycemia-induced decrease in FMD can be prevented by local heating (P<0.05). These effects on FMD were observed in both groups. Our data indicate that non-metabolically driven elevation in BF and shear rate can similarly prevent the hyperglycemia-induced decline in conduit artery endothelial function in healthy volunteers and in patients with type 2 diabetes. Additional research is warranted to confirm that other interventions increasing BF and shear rate equally protect the endothelium when challenged by hyperglycemia.
- cardiovascular risk
- flow mediated dilation
- endothelial function
- shear rate
- Copyright © 2014, Journal of Applied Physiology