The time-course of changes in serum bone turnover markers following an acute bout of resistance training (RT) or plyometrics (PLY) has not been well characterized. This study is the first to compare the acute response of bone formation and resorption markers to a single-bout of RT or PLY. Using a partially randomized, cross-over study design, 12 males completed 4 exercise trials: RT (FED/FASTED) and PLY (FED/FASTED). In addition, 5 of the participants completed a fasted, no-exercise control trial (CON). Blood was drawn prior to exercise, immediately following exercise, 15 min, 30 min, 1 h, 2 h and 24 h following pre-exercise for determination of serum bone-specific alkaline phosphatase (BAP), osteocalcin (OC), tartrate-resistant acid phosphatase 5b (TRAP5b), C-terminal telopeptide of type I collagen (CTX), testosterone, parathyroid hormone (PTH) and cortisol. TRAP5b transiently decreased during the 2 h following all exercise trials (p<0.05), but returned to baseline 2 h post-exercise. BAP, CTX, and OC remained unchanged except for reductions in BAP and CTX following PLY-FASTED and PLY-FED, respectively. BAP decreased during CON. Generally, hormone concentrations decreased during the 2 h following PLY or RT, and cumulative decreases in TRAP5b during the 2 h following exercise were positively correlated with cumulative decreases in PTH. The results of the present study suggest that the timing of the measurement of bone turnover markers relative to the last exercise bout is important for detection of exercise-associated changes in bone turnover markers, as the markers returned to pre-exercise values within 2 h of RT or PLY.
- bone turnover markers
- bone formation
- bone resorption
- tartrate-resistant acid phosphatase 5b
- Copyright © 2011, Journal of Applied Physiology