To study the effect of ventilation strategy on perfluorochemical (PFC) elimination profile (evaporative loss profile; EL), 6 ml/kg of perflubron were instilled into anesthetized normal rabbits. The strategy was to maintain minute ventilation (V˙e, in ml/min) in three groups:V˙e L (low-range V˙e, 208 ± 2), V˙e M (midrangeV˙e, 250 ± 9), andV˙e H (high-range V˙e, 293 ± 1) over 4 h. In three other groups, respiratory rate (RR, breaths/min) was controlled at 20, 30, or 50 with a constant V˙e and adjusted tidal volume. PFC content in the expired gas was measured, and EL was calculated. There was a significant V˙e- and time-dependent effect on EL. Initially, percent PFC saturation and loss rate decreased in the V˙e H >V˙e M >V˙e L groups, but by 3 h the lower percent PFC saturation resulted in a loss rate such thatV˙e H <V˙e M <V˙e L at 4 h. For the groups at constant V˙e, there was a significant time effect on EL but no RR effect. In conclusion, EL profile is dependent on V˙e with little effect of the RR-tidal volume combination. Thus measurement of EL andV˙e should be considered for the replacement dosing schemes during partial liquid ventilation.
- partial liquid ventilation
- minute ventilation
This work was performed at Temple University School of Medicine and was supported in part by Alliance Pharmaceutical.
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