Journal of Applied Physiology


To study the effect of ventilation strategy on perfluorochemical (PFC) elimination profile (evaporative loss profile; EL), 6 ml/kg of perflubron were instilled into anesthetized normal rabbits. The strategy was to maintain minute ventilation (V˙e, in ml/min) in three groups:V˙e L (low-range V˙e, 208 ± 2), V˙e M (midrangeV˙e, 250 ± 9), andV˙e H (high-range V˙e, 293 ± 1) over 4 h. In three other groups, respiratory rate (RR, breaths/min) was controlled at 20, 30, or 50 with a constant V˙e and adjusted tidal volume. PFC content in the expired gas was measured, and EL was calculated. There was a significant V˙e- and time-dependent effect on EL. Initially, percent PFC saturation and loss rate decreased in the V˙e H >V˙e M >V˙e L groups, but by 3 h the lower percent PFC saturation resulted in a loss rate such thatV˙e H <V˙e M <V˙e L at 4 h. For the groups at constant V˙e, there was a significant time effect on EL but no RR effect. In conclusion, EL profile is dependent on V˙e with little effect of the RR-tidal volume combination. Thus measurement of EL andV˙e should be considered for the replacement dosing schemes during partial liquid ventilation.

  • partial liquid ventilation
  • minute ventilation
  • elimination
  • rabbit


  • This work was performed at Temple University School of Medicine and was supported in part by Alliance Pharmaceutical.

  • Address for reprint requests and other correspondence: M.-J. Jeng, Dept. of Pediatrics, Children's Medical Center, Veterans General Hospital-Taipei, No. 210, Section 2, Shih-Pei Road, Taipei 11217, Taiwan, ROC (E-mail: mjjeng{at} ortshaffer{at}

  • The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

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