Page 1333: Letters to The Editor.
Retraction of two articles
To the Editor: We are retracting two papers previously published in the Journal of Applied Physiology: 1) Stalcup, S. A., J. S. Lipset, P. M. Legant, P. J. Leuenberger, and R. B. Mellins. Inhibition of converting enzyme activity by acute hypoxia in dogs. J. Appl. Physiol. 46: 227–234, 1979; and 2) Pang, L. M., H. M. O'Brodovich, R. B. Mellins, and S. A. Stalcup. Bradykinin-induced increase in pulmonary vascular permeability in hypoxic sheep. J. Appl. Physiol. 52: 370—375,1982.
We have repeated the experiments that form the basis for these papers and have been unable to confirm the results with respect to bradykinin. We have no scientific explanation for our inability to reproduce our earlier studies with respect to bradykinin. We must, however, conclude that our hypothesis that Po2 closely regulates angiotensin-converting enzyme activity is incorrect. In addition, we are notifying you that we now conclude that the bradykinin data contained in the paper by H. M. O'Brodovich, S. A. Stalcup, L. M. Pang, and R. B. Mellins, entitled Hemodynamic and vasoactive mediator response to experimental respiratory failure, J. Appl. Physiol. 52: 1230–1236, 1982, are incorrect. We regret that we have inadvertently misled you and the readers.
[See H, M. O'Brodovich, J. Kay, and G. Coates. Bradykinin is degraded in hypoxic lungs and does not affect epithelial permeability. J. Appl. Physiol. 59: 1185–1190, 1985.]
S. Alex Stalcup, Joel S. Lipset, Paul M. Legant, Philippe J. Leuenberger, Leila Mei Pang, Hugh M. O'Brodovich, and Robert B. Mellins Department of Pediatrics College of Physicians & Surgeons of Columbia University New York, New York 10032
- Copyright © 1985 the American Physiological Society