Experimental studies are described in which trained unanesthetized dogs were given a single intravenous injection of 2-acetyl-amino-1,3,4-thiadiazole-5-sulfonamide, a carbonic anhydrase inhibitor. Effects on pulmonary ventilation, alveolar gas exchange, arterial blood gas tensions and arterial blood pH were observed. The drug produced a state of hyperventilation associated with a rise in the alveolar-arterial Po2, a fall in alveolar Pco2, a diuresis of alkaline urine and a state of acidosis probably due to CO2 retention and urinary loss of cations. No changes in metabolic rate or the alveolar exchange ratio were noted. Theoretical calculations, made to estimate the pH and Pco2 of the pulmonary capillary blood, indicated that the latter becomes relatively alkaline following injection of the drug.
Submitted on November 2, 1956
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