HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 99/5/1858    most recent 00305.2005v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Iwashita, S. Articles by Flakoll, P. J. Search for Related Content PubMed PubMed Citation Articles by Iwashita, S. Articles by Flakoll, P. J.

Impact of glutamine supplementation on glucose homeostasis during and after exercise

¹Center for Designing Foods to Improve Nutrition, Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa; ²Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennesse; and ³AminoScience Laboratories, Ajinomoto Co. Inc., Kawasaki, Japan

Submitted 15 March 2005 ; accepted in final form 14 July 2005

The interaction of glutamine availability and glucose homeostasis during and after exercise was investigated, measuring whole body glucose kinetics with [3-³H]glucose and net organ balances of glucose and amino acids (AA) during basal, exercise, and postexercise hyperinsulinemic-euglycemic clamp periods in six multicatheterized dogs. Dogs were studied twice in random treatment order: once with glutamine (12 µmol·kg^–1·min^–1; Gln) and once with saline (Con) infused intravenously during and after exercise. Plasma glucose fell by 7 mg/dl with exercise in Con (P < 0.05), but it did not fall with Gln. Gln further stimulated whole body glucose production and utilization an additional 24% above a normal exercise response (P < 0.05). Net hepatic uptake of glutamine and alanine was greater with Gln than Con during exercise (P < 0.05). Net hepatic glucose output was increased sevenfold during exercise with Gln (P < 0.05) but not with Con. Net hindlimb glucose uptake was increased similarly during exercise in both groups (P < 0.05). During the postexercise hyperinsulinemic-euglycemic period, glucose production decreased to near zero with Con, but it did not decrease below basal levels with Gln. Gln increased glucose utilization by 16% compared with Con after exercise (P < 0.05). Furthermore, net hindlimb glucose uptake in the postexercise period was increased approximately twofold vs. basal with Gln (P < 0.05) but not with Con. Net hepatic uptake of glutamine during the postexercise period was threefold greater for Gln than Con (P < 0.05). In conclusion, glutamine availability modulates glucose homeostasis during and after exercise, which may have implications for postexercise recovery.

isotopic tracer; glucose kinetics; net organ balance; gluconeogenic amino acid

This article has been cited by other articles:

				A Bassini-Cameron, A Monteiro, A Gomes, J P S Werneck-de-Castro, and L Cameron Glutamine protects against increases in blood ammonia in football players in an exercise intensity-dependent way Br. J. Sports Med., April 1, 2008; 42(4): 260 - 266. [Abstract] [Full Text] [PDF]

				S. Iwashita, C. Mikus, S. Baier, and P. J. Flakoll Glutamine Supplementation Increases Postprandial Energy Expenditure and Fat Oxidation in Humans JPEN J Parenter Enteral Nutr, March 1, 2006; 30(2): 76 - 80. [Abstract] [Full Text] [PDF]