Journal of Applied Physiology AJP: Renal Physiology
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J Appl Physiol 99: 814-821, 2005. First published May 12, 2005; doi:10.1152/japplphysiol.00816.2003
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Subcutaneous PO2 as an index of the physiological limits for hemodilution in the rat

Frederick J. Pearce,1 Christine Waasdorp,2 Howard Hufnagel,2 David Burris,2 Joseph DeFeo,2 Peter Soballe,2 and William R. Drucker1,2

1Department of Resuscitative Medicine, Walter Reed Army Institute of Research, Silver Spring; and 2Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland

Submitted 1 August 2003 ; accepted in final form 9 May 2005

This study was designed to test the hypothesis that changes in subcutaneous PO2 (PscO2) during progressive hemodilution will reliably predict a "critical point" at which tissue O2 consumption (O2) becomes dependent on O2 delivery (O2). Twelve pentobarbital-anesthetized male Sprague-Dawley rats (315–375 g) underwent stepwise exchange of plasma for blood (1.5 ml of plasma for each 1 ml of blood lost). The initial exchange was equal to 25% of the estimated circulatory blood volume, and each subsequent exchange was equal to 10% of the estimated circulatory blood volume. After nine exchanges, the hematocrit (Hct) fell from 42 ± 1 to 6 ± 1%. Cardiac output and O2 extraction rose significantly. PscO2 became significantly reduced (P < 0.05) after exchange of 45% of the blood volume (Hct = 16 ± 1%). O2 became delivery dependent when O2 fell below 21 ml·min–1·kg body wt–1 (mean Hct = 13 ± 1%). Eight control rats undergoing 1:1 blood-blood exchange showed no change in PscO2, pH, HCO3–, or hemodynamics. Measurement of PscO2 may be a useful guide to monitor the adequacy of O2 during hemodilution.

optode; oxygen delivery; oxygen consumption; hemodynamics; critical hematocrit; colloid


Address for reprint requests and other correspondence: F. J. Pearce, Walter Reed Army Institute of Research, Dept. of Resuscitative Medicine, Rm. 1A34, 503 Robert Grant Ave., Silver Spring, MD 20910 (e-mail: frederick.pearce{at}na.amedd.army.mil)






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