HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 99/2/556    most recent 00254.2005v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Pearse, D. B. Articles by Sylvester, J. T. Search for Related Content PubMed PubMed Citation Articles by Pearse, D. B. Articles by Sylvester, J. T.

Effects of tidal volume and respiratory frequency on lung lymph flow

¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, and ²Division of Physiology, Department of Environmental Health Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland

Submitted 4 March 2005 ; accepted in final form 21 March 2005

Ventilation () increases lung lymph flow (L), but the separate effects of tidal volume (VT) and frequency (f) and the role of -induced changes in edema formation are poorly understood. An isolated, in situ sheep lung preparation was used to examine these effects. In eight sheep with f = 10 min^–1, results obtained during 30-min periods with VT = 5 or 20 ml/kg were compared with values obtained during bracketed 30-min control periods (VT = 12.5 ml/kg). Eight other sheep with constant VT (12.5 ml/kg) were studied at f = 5 or 20 min^–1 and compared with f = 10 min^–1. Three additional groups of six sheep were perfused for 100 min with control (10 ml/kg, 10 min^–1). VT was then kept constant or changed to 20 or 3 ml/kg during a second 100-min period. Increases in VT or f increased L and vice versa, without corresponding effects on the rate of edema formation. For the same change in , changing VT had a greater effect on L than changing f. The change in L caused by an increase in VT was significantly greater after the accumulation of interstitial edema. The change in L caused by a sustained increase in VT was transient and did not correlate with the rate of edema formation, suggesting that altered L through direct mechanical effects on edema-filled compartments and lymphatic vessels rather than through -induced changes in fluid filtration.

pulmonary edema; sheep; lung fluid balance; lung interstitial space; edema clearance

This article has been cited by other articles:

				N. Soni and P. Williams Positive pressure ventilation: what is the real cost? Br. J. Anaesth., October 1, 2008; 101(4): 446 - 457. [Abstract] [Full Text] [PDF]

				J. Yin, J. Hoffmann, S. M. Kaestle, N. Neye, L. Wang, J. Baeurle, W. Liedtke, S. Wu, H. Kuppe, A. R. Pries, et al. Negative-Feedback Loop Attenuates Hydrostatic Lung Edema via a cGMP-Dependent Regulation of Transient Receptor Potential Vanilloid 4 Circ. Res., April 25, 2008; 102(8): 966 - 974. [Abstract] [Full Text] [PDF]

				E. M. Snyder, K. C. Beck, M. L. Hulsebus, J. F. Breen, E. A. Hoffman, and B. D. Johnson Short-term hypoxic exposure at rest and during exercise reduces lung water in healthy humans J Appl Physiol, December 1, 2006; 101(6): 1623 - 1632. [Abstract] [Full Text] [PDF]