HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free Supplemental Appendix All Versions of this Article: 99/2/458    most recent 00796.2004v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Naire, S. Articles by Jensen, O. E. Search for Related Content PubMed PubMed Citation Articles by Naire, S. Articles by Jensen, O. E.

Epithelial cell deformation during surfactant-mediated airway reopening: a theoretical model

¹Department of Mathematics, Heriot-Watt University, Riccarton, Edinburgh; and ²Centre for Mathematical Medicine, School of Mathematical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

Submitted 27 July 2004 ; accepted in final form 24 March 2005

A theoretical model is presented describing the reopening by an advancing air bubble of an initially liquid-filled collapsed airway lined with deformable epithelial cells. The model integrates descriptions of flow-structure interaction (accounting for nonlinear deformation of the airway wall and viscous resistance of the airway liquid flow), surfactant transport around the bubble tip (incorporating physicochemical parameters appropriate for Infasurf), and cell deformation (due to stretching of the airway wall and airway liquid flows). It is shown how the pressure required to drive a bubble into a flooded airway, peeling apart the wet airway walls, can be reduced substantially by surfactant, although the effectiveness of Infasurf is limited by slow adsorption at high concentrations. The model demonstrates how the addition of surfactant can lead to the spontaneous reopening of a collapsed airway, depending on the degree of initial airway collapse. The effective elastic modulus of the epithelial layer is shown to be a key determinant of the relative magnitude of strains generated by flow-induced shear stresses and by airway wall stretch. The model also shows how epithelial-layer compressibility can mediate strains arising from flow-induced normal stresses and stress gradients.

recruitment; atelectrauma; volutrauma; fluid-structure interaction; surface tension

This article has been cited by other articles:

				H. C. Yalcin, K. M. Hallow, J. Wang, M. T. Wei, H. D. Ou-Yang, and S. N. Ghadiali Influence of cytoskeletal structure and mechanics on epithelial cell injury during cyclic airway reopening Am J Physiol Lung Cell Mol Physiol, November 1, 2009; 297(5): L881 - L891. [Abstract] [Full Text] [PDF]

				H. L. Dailey, L. M. Ricles, H. C. Yalcin, and S. N. Ghadiali Image-based finite element modeling of alveolar epithelial cell injury during airway reopening J Appl Physiol, January 1, 2009; 106(1): 221 - 232. [Abstract] [Full Text] [PDF]

				E. D'Angelo, M. Pecchiari, and G. Gentile Dependence of lung injury on surface tension during low-volume ventilation in normal open-chest rabbits J Appl Physiol, January 1, 2007; 102(1): 174 - 182. [Abstract] [Full Text] [PDF]

				S. J. Weekley, S. L. Waters, and O. E. Jensen Transient elastohydrodynamic drag on a particle moving near a deformable wall Q J Mechanics Appl Math, May 1, 2006; 59(2): 277 - 300. [Abstract] [Full Text] [PDF]