HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 99/1/363    most recent 00822.2004v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Starr, I. R. Articles by Hlastala, M. P. Search for Related Content PubMed PubMed Citation Articles by Starr, I. R. Articles by Hlastala, M. P.

HIGHLIGHTED TOPICS
Pulmonary Circulation and Hypoxia

Regional hypoxic pulmonary vasoconstriction in prone pigs

Departments of ¹Medicine, and ²Physiology and Biophysics, University of Washington, Seattle; and ³Mountain Whisper Light Statistical Consulting, Seattle, Washington

Submitted 2 August 2004 ; accepted in final form 15 March 2005

Hypoxic pulmonary vasoconstriction (HPV) is known to affect regional pulmonary blood flow distribution. It is unknown whether lungs with well-matched ventilation ()/perfusion () have regional differences in the HPV response. Five prone pigs were anesthetized and mechanically ventilated (positive end-expiratory pressure = 2 cmH₂O). Two hypoxic preconditions [inspired oxygen fraction (FI_O2) = 0.13] were completed to stabilize the animal's hypoxic response. Regional pulmonary blood and distribution was determined at various FI_O2 (0.21, 0.15, 0.13, 0.11, 0.09) using the fluorescent microsphere technique. and in the lungs were quantified within 2-cm³ lung pieces. Pieces were grouped, or clustered, based on the changes in blood flow when subjected to increasing hypoxia. Unique patterns of response to hypoxia were seen within and across animals. The three main patterns (clusters) showed little initial difference in / matching at room air where the mean / range was 0.92–1.06. The clusters were spatially located in cranial, central, and caudal portions of the lung. With decreasing FI_O2, blood flow shifted from the cranial to caudal regions. We determined that pulmonary blood flow changes, caused by HPV, produced distinct response patterns that were seen in similar regions across our prone porcine model.

hypoxia; altitude; pulmonary vascular resistance

This article has been cited by other articles:

				A. R. Carvalho, P. M. Spieth, P. Pelosi, A. Beda, A. J. Lopes, B. Neykova, A. R. Heller, T. Koch, and M. Gama de Abreu Pressure Support Ventilation and Biphasic Positive Airway Pressure Improve Oxygenation by Redistribution of Pulmonary Blood Flow Anesth. Analg., September 1, 2009; 109(3): 856 - 865. [Abstract] [Full Text] [PDF]

				T. J. Arai, A. C. Henderson, D. J. Dubowitz, D. L. Levin, P. J. Friedman, R. B. Buxton, G. K. Prisk, and S. R. Hopkins Hypoxic pulmonary vasoconstriction does not contribute to pulmonary blood flow heterogeneity in normoxia in normal supine humans J Appl Physiol, April 1, 2009; 106(4): 1057 - 1064. [Abstract] [Full Text] [PDF]

				S. R. Hopkins, A. Kleinsasser, S. Bernard, A. Loeckinger, E. Falor, B. Neradilek, N. L. Polissar, and M. P. Hlastala Hypoxia has a greater effect than exercise on the redistribution of pulmonary blood flow in swine J Appl Physiol, December 1, 2007; 103(6): 2112 - 2119. [Abstract] [Full Text] [PDF]

				H. T. Robertson and M. P. Hlastala Microsphere maps of regional blood flow and regional ventilation J Appl Physiol, March 1, 2007; 102(3): 1265 - 1272. [Abstract] [Full Text] [PDF]