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³He MRI-based assessment of posture-dependent regional ventilation gradients in rats

¹Department of Experimental Research, Malmö University Hospital, ²Amersham Health Research and Development, Medeon, and ³Department of Clinical Physiology, Malmö University Hospital, Malmö, Sweden

Submitted 8 March 2004 ; accepted in final form 4 January 2005

A recently developed method for quantitative assessment of regional lung ventilation was employed for the study of posture-dependent ventilation differences in rats. The measurement employed hyperpolarized ³He MRI to detect the build-up of the signal intensity after increasing numbers of ³He breaths, which allowed for computation of a regional ventilation parameter. A group of six anesthetized rats was studied in both supine and prone postures. Three-dimensional maps of the ventilation parameter were obtained with high spatial resolution (voxel volume 2 mm³). Vertical (dorsal-ventral) gradients of the ventilation index, defined as the regional ventilation normalized by the average ventilation within the whole lung, were investigated. Variations in the regional distribution of the ventilation parameter, as well as of the ventilation index, could be detected, depending on the posture of the rats. In supine posture, ventilation was elevated in the dependent parts of the lungs, with a linear gradient of the ventilation index of –0.11 ± 0.03 cm^–1. In prone posture, the distribution of ventilation was more uniform, with a significantly (P < 0.001) smaller gradient of the ventilation index of –0.01 ± 0.02 cm^–1. It is concluded that the ³He MRI-based method can detect and quantify regional ventilation gradients in animals as small as the rat and that these gradients depend on prone or supine posture of the animal.

hyperpolarized gas magnetic resonance imaging; helium-3; lung function; posture dependence

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