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J Appl Physiol 98: 1949-1954, 2005. First published January 27, 2005; doi:10.1152/japplphysiol.00952.2004
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HIGHLIGHTED TOPICS
Biomechanics and Mechanotransduction in Cells and Tissues

Chronic strain alters the passive and contractile properties of rabbit airways

R. S. Tepper,1 R. Ramchandani,1 E. Argay,2 L. Zhang,1 Z. Xue,1 Y. Liu,1 and S. J. Gunst2

Department of 1Pediatrics, HB Wells Center for Pediatric Research, and 2Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana

Submitted 1 September 2004 ; accepted in final form 1 December 2004

Pathophysiological conditions of the lung may shift the balance of forces so as to chronically alter the amount of strain imposed on the airways. This chronic strain could result in changes in the structure and/or function of the airways that affect its physiological properties. We evaluated the effects of imposing physiological levels of chronic mechanical strain on the passive and active physiological properties of intraparenchymal rabbit airways. Isolated bronchial segments were cultured for 48 h at transmural pressures of 0 cmH2O (No Strain) or 7 cmH2O (Strain). Effects of strain on small parenchymal airways were evaluated in lung tissue slices cultured under conditions of No Strain or ~50% increased in diameter (Strain). Chronic strain resulted in a higher passive compliance of the bronchial segments and larger airway lumen size. In addition, bronchi not subjected to chronic Strain were more responsive to ACh than bronchi subjected to chronic Strain, and airways in lung slices subjected to No Strain narrowed more in response to ACh than airways in lung slices subjected to Strain. The greatest effects of chronic strain occurred in the smallest sized airways. Our results suggest that chronic distension of the airways has physiologically important effects on their passive and active properties, which are most prominent in the smaller, more peripheral airways.

peripheral airways; mechanical stretch


Address for reprint requests and other correspondence: R. S. Tepper, James Whitcomb Riley Hospital for Children, Section of Pediatric Pulmonology, Rm. 2750, 702 Barnhill Dr., Indianapolis, IN 46202 (E-mail: rtepper{at}iupui.edu)




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