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J Appl Physiol 98: 1258-1263, 2005. First published November 12, 2004; doi:10.1152/japplphysiol.00991.2004
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Inter- and intrastrain variation in mouse critical running speed

Veronique L. Billat,1 Etienne Mouisel,1,2 Natacha Roblot,2 and Judith Melki2

1Unité de Formation et de Recherche Fondamentale et Appliquée, Laboratory of Exercise Physiology EA3872, and 2Molecular Neurogenetics Laboratory, Institut National de la Santé et de la Recherche Médicale, E223, University of Evry, Evry, France

Submitted 9 September 2004 ; accepted in final form 5 November 2004

With the generation of mouse models of human cardiovascular or neuromuscular disorders, the development of noninvasive methods to evaluate the physiological responses to exercise presents an important challenge. The possibility for determining critical speed (CS) in the mouse model was examined according to strain (CD1, C57BL/6J, FVB/N) and sex. Sixty mice performed four exhaustive runs on a treadmill to determine their CS. Twenty-one performed an incremental test to determine the velocity at the lactate threshold. CS was significantly different between the strains (P < 0.0001) but not between sexes. Two measures of heritability showed that CS was partially heritable. CS was not significantly different from lactate threshold velocity. We conclude that CS, which reflects the aerobic capacity, can be determined in mice, as in humans and horses. Considering the intrastrain variability, CS could represent a valuable means for designing an optimal and individualized physical training in mice.

heritability; exercise


Address for reprint requests and other correspondence: V. L. Billat, Laboratory of Exercise Physiology, UFRSFA, Université d'Evry-Val d'Essonne Boulevard François Mitterrand, 94025 Evry Cedex France (E-mail: veronique.billat{at}wanadoo.fr)




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