| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
Submitted 10 September 2004 ; accepted in final form 8 December 2004
Respiratory long-term facilitation (LTF) declines in middle-aged vs. adult male rats. Chronic intermittent hypoxia (CIH; 5 min 11–12% O2/5 min air, 12 h/night, 7 nights) enhances LTF in adult rats. However, LTF in immature rats and the effect of early CIH are unevaluated. The present study compared LTF in 1- and 2-mo-old rats and examined the effect of neonatal CIH (initiated at 2 days after birth) on the LTF. Ventilatory LTF, elicited by 5 (protocol 1) or 10 (protocol 2) episodes of poikilocapnic hypoxia (5 min 12% O2/5 min air), was measured twice by plethysmography on the same male conscious rat when it was 1 and 2 mo old. In untreated (without CIH) rats, both resting ventilation (54.7 ± 0.6 vs. 43.0 ± 0.2 ml·100 g–1·min–1) and hypoxic ventilatory response (131 ± 4 vs. 66 ± 3% above baseline) were greater in 1- vs. 2-mo-old rats. Protocol 1 elicited LTF in 1-mo-old (12.5 ± 1.0% above baseline) but not 2-mo-old rats. Protocol 2 elicited a greater LTF in 1-mo-old (24.3 ± 0.8%) vs. 2-mo-old rats (18.2 ± 0.5%). In CIH-treated rats, protocol 1 also elicited LTF in 1-mo-old (13.1 ± 1.5%) but not 2-mo-old rats. Protocol 2 elicited LTF in both age groups, but LTF was enhanced by the CIH only in 1-mo-old rats (28.8 ± 0.9%). These results suggest that ventilatory LTF and hypoxic ventilatory response are greater in male rats shortly before their sexual maturity and that the neonatal CIH somewhat enhances ventilatory LTF 
3 wk after CIH, but this enhancement does not last to adulthood.
respiratory control; plasticity; intermittent; hypoxia; development
This article has been cited by other articles:
|
|
 |
|
  D. S. Lee, M. S. Badr, and J. H. Mateika Progressive augmentation and ventilatory long-term facilitation are enhanced in sleep apnoea patients and are mitigated by antioxidant administration J. Physiol., November 15, 2009; 587(22): 5451 - 5467. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kervern, C. Dubois, M. Naassila, M. Daoust, and O. Pierrefiche Perinatal Alcohol Exposure in Rat Induces Long-Term Depression of Respiration after Episodic Hypoxia Am. J. Respir. Crit. Care Med., April 1, 2009; 179(7): 608 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Mateika and G. Narwani Intermittent hypoxia and respiratory plasticity in humans and other animals: does exposure to intermittent hypoxia promote or mitigate sleep apnoea? Exp Physiol, March 1, 2009; 94(3): 279 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. McGuire, C. Liu, Y. Cao, and L. Ling Formation and maintenance of ventilatory long-term facilitation require NMDA but not non-NMDA receptors in awake rats J Appl Physiol, September 1, 2008; 105(3): 942 - 950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Bavis and G. S. Mitchell Long-term effects of the perinatal environment on respiratory control J Appl Physiol, April 1, 2008; 104(4): 1220 - 1229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Julien, A. Bairam, and V. Joseph Chronic intermittent hypoxia reduces ventilatory long-term facilitation and enhances apnea frequency in newborn rats Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1356 - R1366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tadjalli, J. Duffin, Y. M. Li, H. Hong, and J. Peever Inspiratory activation is not required for episodic hypoxia-induced respiratory long-term facilitation in postnatal rats J. Physiol., December 1, 2007; 585(2): 593 - 606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Varney and E. H. Schlenker Thyroid status affects 5-HT2A receptor modulation of breathing before, during, and following exposure of hamsters to acute intermittent hypoxia Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R2070 - R2080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Berner, Y. Shvarev, H. Lagercrantz, A. Bilkei-Gorzo, T. Hokfelt, and R. Wickstrom Altered respiratory pattern and hypoxic response in transgenic newborn mice lacking the tachykinin-1 gene J Appl Physiol, August 1, 2007; 103(2): 552 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mahamed and G. S. Mitchell Sleep Apnoea & Hypertension: Physiological bases for a causal relation: Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnoea? Exp Physiol, January 1, 2007; 92(1): 27 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Braga, R. N. Soriano, and B. H. Machado Sympathoexcitatory response to peripheral chemoreflex activation is enhanced in juvenile rats exposed to chronic intermittent hypoxia Exp Physiol, November 1, 2006; 91(6): 1025 - 1031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Reeves, G. S. Mitchell, and D. Gozal Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1664 - R1671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. McGuire, Y. Zhang, D. P. White, and L. Ling Phrenic long-term facilitation requires NMDA receptors in the phrenic motonucleus in rats J. Physiol., September 1, 2005; 567(2): 599 - 611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Cummings and R. J. A. Wilson Time-dependent modulation of carotid body afferent activity during and after intermittent hypoxia Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1571 - R1580. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
