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This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 98/3/1057    most recent 00233.2004v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Hong, S. Articles by Mills, P. J. Search for Related Content PubMed PubMed Citation Articles by Hong, S. Articles by Mills, P. J.

Attenuation of T-lymphocyte demargination and adhesion molecule expression in response to moderate exercise in physically fit individuals

Departments of ¹Psychiatry and ²Medicine, University of California, San Diego, California

Submitted 9 March 2004 ; accepted in final form 20 October 2004

The effects of physical fitness on leukocyte demargination and cellular adhesion molecule (CAM) responses to moderate exercise were examined. We assessed leukocyte subsets and CAM expression before, immediately after, and 10 min after a 20-min treadmill exercise at 65–70% peak oxygen consumption in fit vs. nonfit individuals. Physical fitness was determined by peak oxygen consumption during a treadmill test. Catecholamine levels were determined by radioenzymatic assay, and enumeration of cells and detection of CAM expression were assessed by flow cytometry. As expected, exercise led to significant increases in numbers of leukocyte subsets, regardless of fitness level (P < 0.01). Values returned to near resting levels 10 min after exercise. More importantly, physically fit individuals showed attenuated responses to the moderate-exercise challenge in numbers of CD3⁺, CD4⁺, CD8⁺, memory (CD45RO⁺) CD4, and naive (CD45RA⁺62L⁺) CD4 and CD8 lymphocytes. Postexercise human leukocyte antigen-DR absent memory CD4⁺ cell numbers were also lower in fit subjects. Increases in CD62L-expressing CD4⁺ and CD8⁺ lymphocytes and CD11a- expressing lymphocytes after exercise were also attenuated in fit individuals compared with nonfit individuals (P < 0.05). Catecholamine levels increased to a similar extent (P < 0.01) in both fitness groups. The findings suggest that physical fitness attenuates demargination of selected lymphocyte subsets in response to moderate exercise. Although the differences in plasma catecholamine responses were not significant between the groups, a possible mediating role of the sympathetic system remains to be further investigated. Being physically fit may offset exaggerated immune cell responses to stress.

adrenergic system; catecholamines; fitness

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