Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 97: 1915-1922, 2004. First published July 2, 2004; doi:10.1152/japplphysiol.00505.2004
8750-7587/04 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
97/5/1915    most recent
00505.2004v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Van Voorhies, W. A.
Right arrow Articles by Curtsinger, J. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Van Voorhies, W. A.
Right arrow Articles by Curtsinger, J. W.

Testing the "rate of living" model: further evidence that longevity and metabolic rate are not inversely correlated in Drosophila melanogaster

Wayne A. Van Voorhies,1 Aziz A. Khazaeli,2 and James W. Curtsinger2

1Molecular Biology Program, New Mexico State University, Las Cruces, New Mexico 88003-8001; and 2Department of Ecology, Evolution, and Behavior, University of Minnesota, St. Paul, Minnesota 55108

Submitted 11 May 2004 ; accepted in final form 24 June 2004

In a recent study examining the relationship between longevity and metabolism in a large number of recombinant inbred Drosophila melanogaster lines, we found no indication of the inverse relationship between longevity and metabolic rate that one would expect under the classical "rate of living" model. A potential limitation in generalizing from that study is that it was conducted on experimental material derived from a single set of parental strains originally developed over 20 years ago. To determine whether the observations made with those lines are characteristic of the species, we studied metabolic rates and longevities in a second, independently derived set of recombinant inbred lines. We found no correlation in these lines between metabolic rate and longevity, indicating that the ability to both maintain a normal metabolic rate and have extended longevity may apply to D. melanogaster in general. To determine how closely our measurements reflect metabolic rates of flies maintained under conditions of life span assays, we used long-term, flow-through metabolic rate measurements and closed system respirometry to examine the effects of variables such as time of day, feeding state, fly density, mobility of the flies, and nitrogen knockout on D. melanogaster metabolic rate. We found that CO2 production estimated in individual flies accurately reflects metabolic rates of flies under the conditions used for longevity assays.

aging; respiratory quotient


Address for reprint requests and other correspondence: W. Van Voorhies, Molecular Biology Program, MSC 3MLS, New Mexico State Univ., Las Cruces, NM 88003-8001 (E-mail: wvanvoor{at}nmsu.edu).




This article has been cited by other articles:


Home page
 MicrobiologyHome page
A. L. Dawe, W. A. Van Voorhies, T. A. Lau, A. V. Ulanov, and Z. Li
Major impacts on the primary metabolism of the plant pathogen Cryphonectria parasitica by the virulence-attenuating virus CHV1-EP713
Microbiology, December 1, 2009; 155(12): 3913 - 3921.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
W. A. Van Voorhies
Metabolic function in Drosophila melanogaster in response to hypoxia and pure oxygen
J. Exp. Biol., October 1, 2009; 212(19): 3132 - 3141.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
O. Evans, E. P. Caragata, C. J. McMeniman, M. Woolfit, D. C. Green, C. R. Williams, C. E. Franklin, S. L. O'Neill, and E. A. McGraw
Increased locomotor activity and metabolism of Aedes aegypti infected with a life-shortening strain of Wolbachia pipientis
J. Exp. Biol., May 15, 2009; 212(10): 1436 - 1441.
[Abstract] [Full Text] [PDF]

Home page
 Proc R Soc BHome page
C. Selman, J. S McLaren, A. R Collins, G. G Duthie, and J. R Speakman
The impact of experimentally elevated energy expenditure on oxidative stress and lifespan in the short-tailed field vole Microtus agrestis
Proc R Soc B, August 22, 2008; 275(1645): 1907 - 1916.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. M. Celotto, A. C. Frank, S. W. McGrath, T. Fergestad, W. A. Van Voorhies, K. F. Buttle, C. A. Mannella, and M. J. Palladino
Mitochondrial Encephalomyopathy in Drosophila
J. Neurosci., January 18, 2006; 26(3): 810 - 820.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
S. V. Nuzhdin, A. A. Khazaeli, and J. W. Curtsinger
Survival Analysis of Life Span Quantitative Trait Loci in Drosophila melanogaster
Genetics, June 1, 2005; 170(2): 719 - 731.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. A. Khazaeli, W. Van Voorhies, and J. W. Curtsinger
Longevity and Metabolism in Drosophila melanogaster: Genetic Correlations Between Life Span and Age-Specific Metabolic Rate in Populations Artificially Selected for Long Life
Genetics, January 1, 2005; 169(1): 231 - 242.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2004 by the American Physiological Society.