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J Appl Physiol 97: 1309-1312, 2004. First published June 4, 2004; doi:10.1152/japplphysiol.00284.2004
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Epinephrine infusion increases adipose interleukin-6 gene expression and systemic levels in humans

Pernille Keller, Charlotte Keller, Lindsay E. Robinson, and Bente K. Pedersen

Department of Infectious Diseases and The Copenhagen Muscle Research Center, University Hospital of Copenhagen, Copenhagen 2200-DK, Denmark

Submitted 19 March 2004 ; accepted in final form 27 May 2004

Exercise increases IL-6 mRNA in subcutaneous adipose tissue; however, the immediate signal for the IL-6 induction is unknown. We, therefore, explored the possible role of epinephrine in the induction of IL-6 in adipose tissue. Subcutaneous adipose tissue biopsies and blood samples were obtained from eight healthy men (mean age 27 yr, mean height 184 cm, mean weight 83 kg) in response to epinephrine infusion or in response to saline infusion. The rate of epinephrine infusion was such that circulating epinephrine concentrations mimicked that typically seen during exercise. The level of IL-6 mRNA in subcutaneous adipose tissue increased 26-fold (95% confidence interval, 9- to 166-fold) at 3 h of epinephrine infusion compared with controls (P = 0.028). In addition, plasma levels of IL-6 increased in response to epinephrine infusion (P < 0.001). However, epinephrine did not affect the IL-6 receptor mRNA. In conclusion, epinephrine acutely increases IL-6 mRNA levels in subcutaneous adipose tissue as well as circulating IL-6 levels in healthy men.

interleukin-6 receptor; tumor necrosis factor; adipose tissue


Address for reprint requests and other correspondence: P. Keller, Dept. of Infectious Diseases and the Copenhagen Muscle Research Center, Univ. Hospital Rigshospitalet, Tagensvej 20, Copenhagen 2200-DK, Denmark (E-mail: pkeller{at}rh.dk).




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