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J Appl Physiol 97: 998-1005, 2004. First published May 7, 2004; doi:10.1152/japplphysiol.01280.2003
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Effects of prior heavy-intensity exercise on pulmonary O2 uptake and muscle deoxygenation kinetics in young and older adult humans

Darren S. DeLorey,1,2 John M. Kowalchuk,1,2,3 and Donald H. Paterson1,2

1Canadian Centre for Activity and Aging, 2School of Kinesiology, and 3Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario, Canada N6A 3K7

Submitted 1 December 2003 ; accepted in final form 27 April 2004

Pulmonary O2 uptake (O2p) and muscle deoxygenation kinetics were examined during moderate-intensity cycling (80% lactate threshold) without warm-up and after heavy-intensity warm-up exercise in young (n = 6; 25 ± 3 yr) and older (n = 5; 68 ± 3 yr) adults. We hypothesized that heavy warm-up would speed O2p kinetics in older adults consequent to an improved intramuscular oxygenation. Subjects performed step transitions (n = 4; 6 min) from 20 W to moderate-intensity exercise preceded by either no warm-up or heavy-intensity warm-up (6 min). O2p was measured breath by breath. Oxy-, deoxy-(HHb), and total hemoglobin and myoglobin (Hbtot) of the vastus lateralis muscle were measured continuously by near-infrared spectroscopy (NIRS). O2p (phase 2; {tau}) and HHb data were fit with a monoexponential model. After heavy-intensity warm-up, oxyhemoglobin (older subjects: 13 ± 9 µM; young subjects: 9 ± 8 µM) and Hbtot (older subjects: 12 ± 8 µM; young subjects: 14 ± 10 µM) were elevated (P < 0.05) relative to the no warm-up pretransition baseline. In older adults, {tau}O2p adapted at a faster rate (P < 0.05) after heavy warm-up (30 ± 7 s) than no warm-up (38 ± 5 s), whereas in young subjects, {tau}O2p was similar in no warm-up (26 ± 7 s) and heavy warm-up (25 ± 5 s). HHb adapted at a similar rate in older and young adults after no warm-up; however, in older adults after heavy warm-up, the adaptation of HHb was slower (P < 0.01) compared with young and no warm-up. These data suggest that, in older adults, O2p kinetics may be limited by a slow adaptation of muscle blood flow and O2 delivery.

near-infrared spectroscopy; muscle oxygen utilization; aging


Address for reprint requests and other correspondence: D. H. Paterson, Canadian Centre for Activity and Aging, School of Kinesiology, The Univ. of Western Ontario, London, Ontario, Canada N6A 3K7 (E-mail: dpaterso{at}uwo.ca).




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