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HIGHLIGHTED TOPICS
Skeletal and Cardiac Muscle Blood Flow

-Adrenoceptor-mediated coronary vasoconstriction is augmented during exercise in experimental diabetes mellitus

Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas 76107-2699

Submitted 16 October 2003 ; accepted in final form 18 February 2004

This study tested whether -adrenoceptor-mediated coronary vasoconstriction is augmented during exercise in diabetes mellitus. Experiments were conducted in dogs instrumented with catheters in the aorta and coronary sinus and with a flow transducer around the circumflex coronary artery. Diabetes was induced with alloxan monohydrate (n = 8, 40 mg/kg iv). Arterial plasma glucose concentration increased from 4.7 ± 0.2 mM in nondiabetic, control dogs (n = 8) to 21.4 ± 1.9 mM 1 wk after alloxan injection. Coronary blood flow, myocardial oxygen consumption (MO₂), aortic pressure, and heart rate were measured at rest and during graded treadmill exercise before and after infusion of the -adrenoceptor antagonist phentolamine (1 mg/kg iv). In untreated diabetic dogs, exercise increased MO₂ 2.7-fold, coronary blood flow 2.2-fold, and heart rate 2.3-fold. Coronary venous PO₂ fell as MO₂ increased during exercise. After -adrenoceptor blockade, exercise increased MO₂ 3.1-fold, coronary blood flow 2.7-fold, and heart rate 2.1-fold. Relative to untreated diabetic dogs, -adrenoceptor blockade significantly decreased the slope of the relationship between coronary venous PO₂ and MO₂. The difference between the untreated and phentolamine-treated slopes was greater in the diabetic dogs than in the nondiabetic dogs. In addition, the decrease in coronary blood flow to intracoronary norepinephrine infusion was significantly augmented in anesthetized, open-chest, -adrenoceptor-blocked diabetic dogs compared with the nondiabetic dogs. These findings demonstrate that -adrenoceptor-mediated coronary vasoconstriction is augmented in alloxan-induced diabetic dogs during physiological increases in MO₂.

coronary blood flow; myocardial oxygen consumption

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