Journal of Applied Physiology Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 96: 1292-1298, 2004. First published December 12, 2003; doi:10.1152/japplphysiol.01064.2003
8750-7587/04 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
96/4/1292    most recent
01064.2003v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (29)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nieman, D. C.
Right arrow Articles by McAnulty, L. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nieman, D. C.
Right arrow Articles by McAnulty, L. S.

Influence of carbohydrate ingestion on immune changes after 2 h of intensive resistance training

D. C. Nieman,1 J. M. Davis,2 V. A. Brown,1 D. A. Henson,1 C. L. Dumke,1 A. C. Utter,1 D. M. Vinci,1 M. F. Downs,1 J. C. Smith,1 J. Carson,2 A. Brown,2 S. R. McAnulty,1 and L. S. McAnulty1

1Departments of Health, Leisure, and Exercise Science, Biology, Family and Consumer Sciences, Fischer Hamilton/Nycom Biochemistry Laboratory, Appalachian State University, Boone, North Carolina 28608; and 2Department of Exercise Science, University of South Carolina, Columbia, South Carolina 29208

Submitted 1 October 2003 ; accepted in final form 2 December 2003

Thirty strength-trained subjects were randomized to carbohydrate (CHO) or placebo (Pla) groups and lifted weights for 2 h (10 exercises, 4 sets each, 10 repetitions, with 2- to 3-min rest intervals). Subjects received 10 ml·kg-1·h-1 CHO (6%) or Pla beverages during the weight training bout. Blood, saliva, and vastus lateralis muscle biopsy samples were collected before and after exercise. Blood cell counts were determined, and plasma was analyzed for IL-6, IL-10, IL-1 receptor antagonist (IL-1ra), IL-8, and cortisol. Muscle was analyzed for glycogen content and relative gene expression of 13 cytokines (IL-1{alpha}, IL-1{beta}, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p35, IL-12p40, IL-15, IFN-{gamma}, TNF-{alpha}) by use of real-time quantitative RT-PCR. Significant but modest increases were measured for plasma IL-6, IL-10, IL-1ra, and IL-8, but the pattern of increase did not differ between CHO and Pla groups. The rate of decrease in muscle glycogen content did not differ between CHO and Pla (P = 0.463). Muscle cytokine mRNA was detected preexercise for IL-1{beta}, IL-6, IL-15, IL-8, and TNF-{alpha}, and of these, IL-1{beta}, IL-6, IL-8, and TNF-{alpha} were significantly increased after the 2-h weight training bout. The increase in mRNA (fold difference from preexercise) did not differ between CHO and Pla groups. In summary, CHO vs. Pla ingestion did not alter modest increases measured for plasma IL-6, IL-10, IL-1ra, and IL-8, and muscle gene expression for IL-1{beta}, IL-6, IL-8, and TNF-{alpha} in strength-trained subjects lifting weights intensively for 2 h.

cytokines; gene expression; muscle glycogen; real-time quantitative reverse transcription polymerase chain reaction


Address for reprint requests and other correspondence: D. C. Nieman, Dept. of Health & Exercise Science, PO Box 32071 Appalachian State Univ., Boone, NC 28608 (E-mail: niemandc{at}appstate.edu).




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
C. M. Dieli-Conwright, T. M. Spektor, J. C. Rice, and E. T. Schroeder
Hormone therapy attenuates exercise-induced skeletal muscle damage in postmenopausal women
J Appl Physiol, September 1, 2009; 107(3): 853 - 858.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
A. Moreira, L. Delgado, P. Moreira, and T. Haahtela
Does exercise increase the risk of upper respiratory tract infections?
Br. Med. Bull., June 1, 2009; 90(1): 111 - 131.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
B. K. Pedersen and M. A. Febbraio
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Physiol Rev, October 1, 2008; 88(4): 1379 - 1406.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. Strle, R. H. McCusker, R. W. Johnson, S. M. Zunich, R. Dantzer, and K. W. Kelley
Prototypical anti-inflammatory cytokine IL-10 prevents loss of IGF-I-induced myogenin protein expression caused by IL-1{beta}
Am J Physiol Endocrinol Metab, April 1, 2008; 294(4): E709 - E718.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
L. S. Quinn
Interleukin-15: A muscle-derived cytokine regulating fat-to-lean body composition
J Anim Sci, April 1, 2008; 86(14_suppl): E75 - E83.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
U. Raue, D. Slivka, B. Jemiolo, C. Hollon, and S. Trappe
Proteolytic Gene Expression Differs At Rest and After Resistance Exercise Between Young and Old Women
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2007; 62(12): 1407 - 1412.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. Louis, U. Raue, Y. Yang, B. Jemiolo, and S. Trappe
Time course of proteolytic, cytokine, and myostatin gene expression after acute exercise in human skeletal muscle
J Appl Physiol, November 1, 2007; 103(5): 1744 - 1751.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. R. Nielsen, R. Mounier, P. Plomgaard, O. H. Mortensen, M. Penkowa, T. Speerschneider, H. Pilegaard, and B. K. Pedersen
Expression of interleukin-15 in human skeletal muscle effect of exercise and muscle fibre type composition
J. Physiol., October 1, 2007; 584(1): 305 - 312.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. K. Pedersen, T. C. A. Akerstrom, A. R. Nielsen, and C. P. Fischer
Role of myokines in exercise and metabolism
J Appl Physiol, September 1, 2007; 103(3): 1093 - 1098.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Yang, B. Jemiolo, and S. Trappe
Proteolytic mRNA expression in response to acute resistance exercise in human single skeletal muscle fibers
J Appl Physiol, November 1, 2006; 101(5): 1442 - 1450.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. M. Bruun, J. W. Helge, B. Richelsen, and B. Stallknecht
Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects
Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E961 - E967.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
H. Bruunsgaard
Physical activity and modulation of systemic low-level inflammation
J. Leukoc. Biol., October 1, 2005; 78(4): 819 - 835.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2004 by the American Physiological Society.