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J Appl Physiol 96: 1127-1136, 2004. First published November 14, 2003; doi:10.1152/japplphysiol.00092.2003
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Physiological evaluation of a new quantitative SPECT method measuring regional ventilation and perfusion

Johan Petersson,1 Alejandro Sánchez-Crespo,2,3 Malin Rohdin,4 Stéphanie Montmerle,4 Sven Nyrén,5 Hans Jacobsson,2,5 Stig A. Larsson,2,3 Sten G. E. Lindahl,1 Dag Linnarsson,4 Robb W. Glenny,1,6 and Margareta Mure1

1Department of Anesthesiology and Intensive Care, 2Section of Nuclear Medicine, Department of Hospital Physics, and 5Department of Radiology, Karolinska Hospital, 171 76 Stockholm; 3Medical Radiation Physics, Department of Oncology-Pathology, Stockholm University and Karolinska Institutet and 4Section of Environmental Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden; and 6Departments of Medicine and Physiology and Biophysics, University of Washington, Seattle, Washington 98195

Submitted 29 January 2003 ; accepted in final form 6 November 2003

We have developed a new quantitative single-photon-emission computed tomography (SPECT) method that uses 113mIn-labeled albumin macroaggregates and Technegas (99mTc) to estimate the distributions of regional ventilation and perfusion for the whole lung. The multiple inert-gas elimination technique (MIGET) and whole lung respiratory gas exchange were used as physiological evaluations of the SPECT method. Regional ventilation and perfusion were estimated by SPECT in nine healthy volunteers during awake, spontaneous breathing. Radiotracers were administered with subjects sitting upright, and SPECT images were acquired with subjects supine. Whole lung gas exchange of MIGET gases and arterial PO2 and PCO2 gases was predicted from estimates of regional ventilation and perfusion. We found a good agreement between measured and SPECT-predicted exchange of MIGET and respiratory gases. Correlations (r2) between SPECT-predicted and measured inert-gas excretions and retentions were 0.99. The method offers a new tool for measuring regional ventilation and perfusion in humans.

single-photon-emission computed tomography; multiple inert-gas elimination technique; gas exchange


Address for reprint requests and other correspondence: J. Petersson, Dept. of Anesthesiology and Intensive Care, Karolinska Hospital, 171 76 Stockholm, Sweden (E-mail: johan.petersson{at}ks.se).




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