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J Appl Physiol 96: 463-468, 2004. First published August 29, 2003; doi:10.1152/japplphysiol.00292.2003
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A computed method for noninvasive MRI assessment of pulmonary arterial hypertension

Eric Laffon,1,2 Christophe Vallet,3 Virginie Bernard,4 Michel Montaudon,5 Dominique Ducassou,1 François Laurent,2,5 and Roger Marthan2

Service de 1Médecine Nucléaire, 4Cardiologie, and 5Radiologie, Hôpital du Haut-Lévêque, 33604 Pessac; 2Laboratoire de Physiologie Cellulaire Respiratoire, Institut National de la Santé et de la Recherche Médicale E 356, Université Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex; and 3École Nationale Supérieure Électronique, Informatique et Radiocommunications, 33402 Talence Cedex, France

Submitted 20 March 2003 ; accepted in final form 28 August 2003

The present method enables the noninvasive assessment of mean pulmonary arterial pressure from magnetic resonance phase mapping by computing both physical and biophysical parameters. The physical parameters include the mean blood flow velocity over the cross-sectional area of the main pulmonary artery (MPA) at the systolic peak and the maximal systolic MPA cross-sectional area value, whereas the biophysical parameters are related to each patient, such as height, weight, and heart rate. These parameters have been measured in a series of 31 patients undergoing right-side heart catheterization, and the computed mean pulmonary arterial pressure value (PpaComp) has been compared with the mean pressure value obtained from catheterization (PpaCat) in each patient. A significant correlation was found that did not differ from the identity line PpaComp = PpaCat (r = 0.92). The mean and maximal absolute differences between PpaComp and PpaCat were 5.4 and 11.9 mmHg, respectively. The method was also applied to compute the MPA systolic and diastolic pressures in the same patient series. We conclude that this computed method, which combines physical (whoever the patient) and biophysical parameters (related to each patient), improves the accuracy of MRI to noninvasively estimate pulmonary arterial pressures.

pulmonary arterial hypertension; magnetic resonance phase mapping; computing; pulmonary arterial blood pressures


Address for reprint requests and other correspondence: E. Laffon, Service de Médecine Nucléaire, Hôpital du Haut-Lévêque, 33604 Pessac, France (E-mail: elaffon{at}u-bordeaux2.fr).




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