Journal of Applied Physiology
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J Appl Physiol 95: 2453-2461, 2003. First published August 22, 2003; doi:10.1152/japplphysiol.00303.2003
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Independent cerebral vasoconstrictive effects of hyperoxia and accompanying arterial hypocapnia at 1 ATA

Thomas F. Floyd,1 James M. Clark,2 Robert Gelfand,2 John A. Detre,3 Sarah Ratcliffe,4 Dimitri Guvakov,1 Christian J. Lambertsen,2 and Roderic G. Eckenhoff1

1Department of Anesthesia, and 2Institute for Environmental Medicine Environmental Biomedical Stress Data Center, and 3Departments of Neurology and 4Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104

Submitted 25 March 2003 ; accepted in final form 20 August 2003

Breathing 100% O2 at 1 atmosphere absolute (ATA) is known to be associated with a decrease in cerebral blood flow (CBF). It is also accompanied by a fall in arterial PCO2 leading to uncertainty as to whether the cerebral vasoconstriction is totally or only in part caused by arterial hypocapnia. We tested the hypothesis that the increase in arterial PO2 while O2 was breathed at 1.0 ATA decreases CBF independently of a concurrent fall in arterial PCO2. CBF was measured in seven healthy men aged 21–62 yr by using noninvasive continuous arterial spin-labeled-perfusion MRI. The tracer in this technique, magnetically labeled protons in blood, has a half-life of seconds, allowing repetitive measurements over short time frames without contamination. CBF and arterial blood gases were measured while breathing air, 100% O2, and 4 and 6% CO2 in air and O2 backgrounds. Arterial PO2 increased from 91.7 ± 6.8 Torr in air to 576.7 ± 18.9 Torr in O2. Arterial PCO2 fell from 43.3 ± 1.8 Torr in air to 40.2 ± 3.3 Torr in O2. CBF-arterial PCO2 response curves for the air and hyperoxic runs were nearly parallel and separated by a distance representing a 28.7–32.6% decrement in CBF. Regression analysis confirmed the independent cerebral vasoconstrictive effect of increased arterial PO2. The present results also demonstrate that the magnitude of this effect at 1.0 ATA is greater than previously measured.

cerebral blood flow; oxygen; carbon dioxide; arterial spin-labeling; magnetic resonance; atmospheres absolute


Address for reprint requests and other correspondence: T. F. Floyd, Dept. of Anesthesia, Section of Cardiovascular & Thoracic Anesthesia, Hospital of the Univ. of Pennsylvania, 4-Dulles, 3400 Spruce St., Philadelphia, PA 19104-4283 (E-mail: floydt{at}uphs.upenn.edu).




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