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Effect of hindlimb suspension on the functional properties of slow and fast soleus fibers from three strains of mice

Department of Exercise and Sport Science, Oregon State University, Corvallis, Oregon 97331

Submitted 27 November 2002 ; accepted in final form 23 August 2003

Cross-sectional area (CSA), peak Ca²⁺-activated force (P_o), fiber specific force (P_o/CSA), and unloaded shortening velocity (V_o) were measured in slow-twitch [containing type I myosin heavy chain (MHC)] and fast-twitch (containing type II MHC) chemically skinned soleus muscle fiber segments obtained from three strains of weight-bearing and 7-day hindlimb-suspended (HS) mice. HS reduced soleus slow MHC content (from 50 to 33%) in CBA/J and ICR strains without affecting slow MHC content in C57BL/6 mice (20% of total MHC). Two-way ANOVA revealed HS-induced reductions in CSA, P_o, and P_o/CSA of slow and fast fibers from all strains. Fiber V_o was elevated post-HS, but not consistently across strains. No MHC x HS treatment interactions were observed for any variable for C57BL/6 and CBA/J mice, and the two significant interactions found for the ICR strain (CSA, P_o) appeared related to inherent pre-HS differences in slow vs. fast fiber CSA. In the mouse HS models studied here, fiber atrophy and contractile dysfunction were partially dependent on animal strain and generally independent of fiber MHC isoform content.

muscle atrophy; hindlimb unweighting; hindlimb unloading; non-weight bearing; spaceflight

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