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J Appl Physiol 95: 1617-1622, 2003. First published July 3, 2003; doi:10.1152/japplphysiol.00408.2003
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Loss of desmin leads to impaired voluntary wheel running and treadmill exercise performance

Kurt W. Haubold,1 David L. Allen,1 Yassemi Capetanaki,2 and Leslie A. Leinwand1

1Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347; and 2Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030

Submitted 24 April 2003 ; accepted in final form 29 June 2003

We examined voluntary wheel running and forced treadmill running exercise performance of wild-type mice and mice null for the desmin gene. When given access to a cage wheel, desmin null mice spent less time running and ran less far than wild-type mice. Wild-type mice showed a significant training effect with prolonged voluntary wheel running, as evidenced by an increase in mean running speed across the 3-wk exercise period, whereas desmin null mice did not. Desmin null mice also performed less well in acute treadmill stress and endurance tests compared with wild-type mice. We also evaluated serum creatine kinase (CK) activity in wild-type and desmin null mice in response to running. Voluntary running did not result in elevated CK activity in either wild-type or desmin null mice, whereas downhill treadmill running caused significant increases in serum CK activity in both wild-type and desmin null mice. However, the increase in serum CK was significantly less in desmin null mice than in wild-type mice. These results suggest that the lack of desmin adversely affects the ability of mice to engage in both chronic and acute bouts of endurance running exercise but that this decrement in performance is not associated with an increase in serum CK activity.

intermediate filaments; serum creatine kinase; dystrophy; skeletal muscle; muscle damage


Address for reprint requests and other correspondence: L. A. Leinwand, Dept. of Molecular, Cellular, and Developmental Biology, Univ. of Colorado, Campus Box 347, Boulder, CO 80309-0347 (E-mail: leinwand{at}ataqdog.colorado.edu).




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