Journal of Applied Physiology Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 95: 1425-1430, 2003. First published June 13, 2003; doi:10.1152/japplphysiol.00516.2003
8750-7587/03 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
95/4/1425    most recent
00516.2003v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (17)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Roth, S. M.
Right arrow Articles by Ferrell, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roth, S. M.
Right arrow Articles by Ferrell, R. E.

C174T polymorphism in the CNTF receptor gene is associated with fat-free mass in men and women

Stephen M. Roth,1,2 E. Jeffrey Metter,3 Mechele R. Lee,1 Ben F. Hurley,2 and Robert E. Ferrell1

1Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261; 2Department of Kinesiology, University of Maryland, College Park, 20742; and 3Clinical Research Branch, National Institute on Aging, Gerontology Research Center, Baltimore, Maryland 21224

Submitted 14 May 2003 ; accepted in final form 11 June 2003

We performed gene screening of the ciliary neurotrophic factor receptor (CNTFR) gene and genotyped three newly identified polymorphisms: C-1703T in the 5' promoter region, T1069A in intron 5, and C174T in exon 9. We studied the association of these CNTFR variants with muscle strength, mass, and body composition in 465 men and women (20-90 yr) from the Baltimore Longitudinal Study of Aging. Only the C174T variant was significantly associated with muscle-related phenotypes. In the entire cohort, when corrected for age, sex, race, physical activity, and height, homozygotes for the common C allele at C174T (CC) exhibited lower total body mass and body mass index than carriers of the rare T allele, which appeared to be due to significant differences in total nonosseous fat-free mass (FFM) (48.0 ± 0.4 vs. 50.0 ± 0.7 kg; P = 0.011) and lower limb FFM (16.5 ± 0.1 vs. 17.2 ± 0.2 kg; P = 0.002). The CC group also exhibited significantly lower quadriceps concentric and eccentric isokinetic strength values at both 30 and 180°/s than the T allele carriers (all P < 0.04), but these differences were no longer significant after adjustment for lower limb FFM. There were no significant sex-by-genotype interactions. The results indicate that the C174T polymorphism in exon 9 of CNTFR is significantly associated with FFM in men and women, with concomitant differences in muscular strength.

genetics; muscle mass; muscle strength; polymorphism; sex; ciliary neurotrophic factor receptor


Address for reprint requests and other correspondence: S. M. Roth, Dept. Kinesiology, Univ. of Maryland, College Park, MD 20742 (E-mail: sroth1{at}umd.edu).




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
S. Walsh, B. K. Kelsey, T. J. Angelopoulos, P. M. Clarkson, P. M. Gordon, N. M. Moyna, P. S. Visich, R. F. Zoeller, R. L. Seip, S. Bilbie, et al.
CNTF 1357 G -> A polymorphism and the muscle strength response to resistance training
J Appl Physiol, October 1, 2009; 107(4): 1235 - 1240.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. De Mars, A. Windelinckx, G. Beunen, C. Delecluse, J. Lefevre, and M. A. I. Thomis
Polymorphisms in the CNTF and CNTF receptor genes are associated with muscle strength in men and women
J Appl Physiol, May 1, 2007; 102(5): 1824 - 1831.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
G. F. Martel, S. M. Roth, F. M. Ivey, J. T. Lemmer, B. L. Tracy, D. E. Hurlbut, E. J. Metter, B. F. Hurley, and M. A. Rogers
Age and sex affect human muscle fibre adaptations to heavy-resistance strength training
Exp Physiol, March 1, 2006; 91(2): 457 - 464.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Walsh, J. M. Zmuda, J. A. Cauley, P. R. Shea, E. J. Metter, B. F. Hurley, R. E. Ferrell, and S. M. Roth
Androgen receptor CAG repeat polymorphism is associated with fat-free mass in men
J Appl Physiol, January 1, 2005; 98(1): 132 - 137.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
S. M. Roth, J. M. Zmuda, J. A. Cauley, P. R. Shea, and R. E. Ferrell
Vitamin D Receptor Genotype Is Associated With Fat-Free Mass and Sarcopenia in Elderly Men
J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2004; 59(1): B10 - 15.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
S. M. Roth, M. A. Schrager, M. R. Lee, E. J. Metter, B. F. Hurley, and R. E. Ferrell
Interleukin-6 (IL6) Genotype Is Associated With Fat-Free Mass in Men But Not Women
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2003; 58(12): B1085 - 1088.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.