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J Appl Physiol 95: 751-757, 2003. First published May 2, 2003; doi:10.1152/japplphysiol.00992.2002
8750-7587/03 $5.00
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Effects of prolonged reduction in blood flow on submandibular secretory function in anesthetized sheep

A. S. Thakor, C. N. Brown, and A. V. Edwards

Physiological Laboratory, University of Cambridge, Cambridge CB2 3EG, United Kingdom

Submitted 28 October 2002 ; accepted in final form 18 December 2002

Submandibular vascular and secretory responses to parasympathetic chorda-lingual (C-L) stimulation were investigated in anesthetized sheep before, during, and after an intracarotid (ic) infusion of endothelin-1 (ET-1). Stimulation of the peripheral end of the C-L nerve at 4 and 8 Hz produced a frequency-dependent reduction in submandibular vascular resistance (SVR) associated with a frequency-dependent increase in submandibular blood flow, salivary flow, and Na+, K+, and protein output from the gland. During stimulation at 4 Hz, ic ET-1 significantly increased SVR (P < 0.01), without significantly affecting either the aortic blood pressure or heart rate. Submandibular blood flow (SBF) was reduced by 48 ± 4% and the flow of saliva by 50 ± 1%. The effect on blood and salivary flow persisted for at least 30 min after the infusion of ET-1. The reduction in SBF was associated with a diminution in the output of Na+,K+, and protein in the saliva (P < 0.01). These effects persisted for 30 min after the infusion of ET-1 had been discontinued and were linearly related to the flow of plasma throughout.

salivary glands; saliva; protein


Address for reprint requests and other correspondence: A. V. Edwards, Physiological Laboratory, Downing St., Cambridge CB2 3EG, UK (E-mail: ave1000{at}cam.ac.uk).






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