Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 95: 677-684, 2003. First published April 25, 2003; doi:10.1152/japplphysiol.00101.2003
8750-7587/03 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
95/2/677    most recent
00101.2003v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (28)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Woo, M. A.
Right arrow Articles by Harper, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Woo, M. A.
Right arrow Articles by Harper, R. M.

Regional brain gray matter loss in heart failure

Mary A. Woo,1 Paul M. Macey,2 Gregg C. Fonarow,3 Michele A. Hamilton,3 and Ronald M. Harper 2,4

1School of Nursing, 2Department of Neurobiology, 4Brain Research Institute, and 3Division of Cardiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095

Submitted 31 January 2003 ; accepted in final form 19 April 2003

Heart failure (HF) patients exhibit enhanced sympathetic tone, aberrant responses to blood pressure challenges, and sleep-related breathing disorders, suggesting that the syndrome is accompanied by central neural deficits. We assessed regional gray matter volumes over the entire brain in nine HF patients (51 ± 10 yr; left ventricular ejection fraction 0.27 ± 0.06; six men) and 27 healthy controls (46 ± 12 yr; 22 men) using T1-weighted magnetic resonance imaging to evaluate potential neural damage. Regional volumes were evaluated by using voxel-based morphometry while controlling for age, gender, and handedness. HF patients showed significant and largely lateralized gray matter loss in autonomic and respiratory-related areas as well as regions not classically associated with such control, including the insula and basal ganglia, right cingulate gyrus, parahippocampal/fusiform gyrus, dorsal midbrain extending to the posterior and medial thalamus, ventral and superior lateral frontal cortex, bilateral cerebellar quadrangular lobules and right fastigial and neighboring nuclei, and bilateral deep parietal and lateral parietal-occipital cortex. Areas of gray matter loss may contribute to inappropriate cognitive, autonomic, and breathing regulation in HF.

autonomic; apnea; magnetic resonance imaging; Cheyne-Stokes; sleep


Address for reprint requests and other correspondence: R. M. Harper, Dept. of Neurobiology, Univ. of California at Los Angeles, 10833 Le Conte Ave., Los Angeles, CA 90095-1763 (E-mail: rharper{at}ucla.edu).




This article has been cited by other articles:


Home page
 CirculationHome page
B. Riegel, D. K. Moser, S. D. Anker, L. J. Appel, S. B. Dunbar, K. L. Grady, M. Z. Gurvitz, E. P. Havranek, C. S. Lee, J. Lindenfeld, et al.
State of the Science: Promoting Self-Care in Persons With Heart Failure: A Scientific Statement From the American Heart Association
Circulation, September 22, 2009; 120(12): 1141 - 1163.
[Full Text] [PDF]

Home page
 Eur J Heart FailHome page
R. L.C. Vogels, W. M. van der Flier, B. van Harten, A. A. Gouw, P. Scheltens, J. M. Schroeder-Tanka, and H. C. Weinstein
Brain magnetic resonance imaging abnormalities in patients with heart failure
Eur J Heart Fail, October 1, 2007; 9(10): 1003 - 1009.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. M. Rector, C. A. Richard, and R. M. Harper
Cerebellar fastigial nuclei activity during blood pressure challenges
J Appl Physiol, August 1, 2006; 101(2): 549 - 555.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. J. Petrucci, K. C. Truesdell, A. Carter, N. E. Goldstein, M. M. Russell, D. Dilkes, J. M. Fitzpatrick, C. E. Thomas, M. E. Keenan, L. A. Lazarus, et al.
Cognitive dysfunction in advanced heart failure and prospective cardiac assist device patients.
Ann. Thorac. Surg., May 1, 2006; 81(5): 1738 - 1744.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
N. S. Cherniack and G. S. Longobardo
Mathematical models of periodic breathing and their usefulness in understanding cardiovascular and respiratory disorders
Exp Physiol, March 1, 2006; 91(2): 295 - 305.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. M. Macey, M. A. Woo, K. E. Macey, T. G. Keens, M. M. Saeed, J. R. Alger, and R. M. Harper
Hypoxia reveals posterior thalamic, cerebellar, midbrain, and limbic deficits in congenital central hypoventilation syndrome
J Appl Physiol, March 1, 2005; 98(3): 958 - 969.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. E. Meadows, D. M. O'Driscoll, A. K. Simonds, M. J. Morrell, and D. R. Corfield
Cerebral blood flow response to isocapnic hypoxia during slow-wave sleep and wakefulness
J Appl Physiol, October 1, 2004; 97(4): 1343 - 1348.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.