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J Appl Physiol 94: 1719-1725, 2003. First published January 17, 2003; doi:10.1152/japplphysiol.00527.2002
8750-7587/03 $5.00
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Vol. 94, Issue 5, 1719-1725, May 2003

Local particle deposition patterns may play a key role in the development of lung cancer

Imre Balásházy1, Werner Hofmann2, and Thomas Heistracher3

1 Radiation and Environmental Physics Department, KFKI Atomic Energy Research Institute, H-1525 Budapest 114, Hungary; 2 Institute of Physics and Biophysics, University of Salzburg; and 3 Department of Informatics and Telematics, Polytechnical University of Salzburg, A-5020 Salzburg, Austria

The apparent discrepancy between the reported preferential occurrence of bronchial carcinomas in central bronchial airways and current dose estimates for inhaled particles suggests that experimentally observed local accumulations of particles within bronchial airway bifurcations may play a crucial role in lung cancer induction. Here, we computed three-dimensional particle deposition patterns in lobar-segmental airway bifurcations and quantified the resulting inhomogeneous deposition patterns in terms of deposition enhancement factors, which are defined as the ratio of local to average deposition densities. Our results revealed that a small fraction of epithelial cells located at carinal ridges can receive massive doses that may be even a few hundred times higher than the average dose for the whole airway. This lends further credence to the hypothesis that the apparent site selectivity of neoplastic lesions may indeed be caused by the enhanced deposition of toxic particulate matter at bronchial airway bifurcations.

inhaled particles; health effects; deposition distributions


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