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J Appl Physiol 94: 1353-1364, 2003. First published December 6, 2002; doi:10.1152/japplphysiol.00612.2002
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Vol. 94, Issue 4, 1353-1364, April 2003

Inter- and intraregional ventilation inhomogeneity in hypergravity and after pressurization of an anti-G suit

Mikael Grönkvist1, Eddie Bergsten1, Ola Eiken1, and Per M. Gustafsson1,2

1 Swedish Defence Research Agency, Defence Medicine, S-580 13 Linköping, and Karolinska Institutet, S-171 77 Stockholm; and 2 Department of Pediatric Clinical Physiology, Queen Silvia Children's Hospital, S-416 85 Göteborg, Sweden

This study assessed the effects of increased gravity in the head-to-foot direction (+Gz) and anti-G suit (AGS) pressurization on functional residual capacity (FRC), the volume of trapped gas (VTG), and ventilation distribution by using inert- gas washout. Normalized phase III slope (SnIII) analysis was used to determine the effects on inter- and intraregional ventilation inhomogeneity. Twelve men performed multiple-breath washouts of SF6 and He in a human centrifuge at +1 to +3 Gz wearing an AGS pressurized to 0, 6, or 12 kPa. Hypergravity produced moderately increased FRC, VTG, and overall and inter- and intraregional inhomogeneities. In normogravity, AGS pressurization resulted in reduced FRC and increased VTG, overall, and inter- and intraregional inhomogeneities. Inflation of the AGS to 12 kPa at +3 Gz reduced FRC markedly and caused marked gas trapping and intraregional inhomogeneity, whereas interregional inhomogeneity decreased. In conclusion, increased +Gz impairs ventilation distribution not only between widely separated lung regions, but also within small lung units. Pressurizing an AGS in hypergravity causes extensive gas trapping accompanied by reduced interregional inhomogeneity and, apparently, results in greater intraregional inhomogeneity.

functional residual capacity; gas trapping; helium and sulfur hexafluoride; multiple-breath washout; normalized phase III slope analysis


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[Abstract] [Full Text] [PDF]


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