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1 Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38105; 2 Department of Physiology, University of Arizona, Tucson, Arizona 85721; 3 PPD Development, Inc., Austin, Texas 78704; 4 Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706; 5 Synarc, Inc. and 7 Department of Epidemiology and Biostatistics, University of California-San Francisco, San Francisco, California 94105; 6 University of Pittsburgh, Pittsburgh, Pennsylvania 15261; 8 Institute for Research in Extramural Medicine, VU University Medical Center, 1081 BT Amsterdam, The Netherlands; and 9 National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892
This study evaluated the accuracy with which the dual-energy X-ray absorptiometer (Hologic QDR 4500A) measured fat-free mass (FFM), fat mass (FM), and hydration of FFM. In a study of 58 men and women (ages 70-79 yr), the QDR 4500A was found to provide a systematically higher estimate of FFM and lower estimate of FM than a four-component model of body composition. A correction factor from this study was developed and applied to two other samples (n = 13 and 37). We found mean corrected levels of FFM and FM to be equivalent to that obtained by the four-component model or total body water. In addition, the hydration of the corrected FFM was closer to the established hydration level in adult samples and that obtained from the four-component model. These findings suggest that the current calibration of the fan-beam system of the Hologic QDR 4500A provides an overestimate of FFM and underestimate of FM compared with reference methods.
body composition; hydration of fat-free mass; four-component model of body composition; total body water; dual-energy X-ray absorptiometer
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