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J Appl Physiol 94: 429-438, 2003. First published December 20, 2002; doi:10.1152/japplphysiol.00018.2001
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Vol. 94, Issue 2, 429-438, February 2003

Reduced respiratory-related evoked activity in subjects with obstructive sleep apnea syndrome

Metin Akay1, J. C. Leiter2,3, and J. Andrew Daubenspeck1,2

1 Thayer School of Engineering, Dartmouth College, and the Departments of 2 Physiology and 3 Medicine, Dartmouth Medical School, Hanover, New Hampshire 03756

Midlatency respiratory-related evoked potentials were measured during wakefulness by using a 60-electrode array placed over the cortical region of the scalp. We studied the responses evoked by 200-ms pressure pulses at -5 and -10 cmH2O applied at inspiratory onset and during control tests (no pressure applied) in 14 subjects with obstructive sleep apnea syndrome (OSAS) and 18 normal subjects. Wavelet decomposition was used to smooth and dissect the respiratory-related evoked potentials in frequency and time in 8 frequency bands. After denoising, selected wavelet scales were used to reconstruct the respiratory-related evoked potentials, which were quantified by using global field power estimates. The time course of the global field power activity in OSAS subjects compared with normal subjects was significantly depressed in the period 55-70 ms poststimulus onset, a time when afferent traffic from upper airway receptors arrives in normal subjects. The reduced evoked response in subjects with OSAS suggests that these subjects receive less afferent input from upper airway mechanoreceptors. This may reflect reduced sensitivity of mechanoreceptors or reduced mechanoreceptor stimulation due to decreased upper airway compliance during wakefulness in OSAS.

respiratory mechanoreceptors; mechanoreceptor afferent activity; event-related potentials; sleep disordered breathing; global field power; time-frequency analysis; wavelet analysis


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