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1 Department of Exercise Science, University of Massachusetts, Amherst, Massachusetts 01003; 2 Exercise Science Program, Marquette University, Milwaukee, Wisconsin 53201; and 3 Magnetic Resonance Unit, Department of Radiology, University of California, San Francisco, California 94121
The purpose of this study
was to compare the magnitude and mechanisms of ankle dorsiflexor muscle
fatigue in 20 young (33 ± 6 yr, mean ± SD) and 21 older
(75 ± 6 yr) healthy men and women of similar physical activity
status. Noninvasive measures of central and peripheral (neuromuscular
junction, sarcolemma) muscle activation, muscle contractile function,
and intramuscular energy metabolism were made before, during, and after
incremental isometric exercise. Older subjects fatigued less than young
(P < 0.01); there was no effect of gender on fatigue
(P = 0.24). For all subjects combined, fatigue was
modestly related to preexercise strength (r = 0.49, P < 0.01). Neither central (central activation ratio)
nor peripheral (compound muscle action potential) activation played a
significant role in fatigue in any group. During exercise,
intracellular concentrations of Pi and
H2PO
physical activity; magnetic resonance spectroscopy; central fatigue; activation; excitation-contraction coupling; metabolism
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