Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 93: 1709-1715, 2002. First published July 12, 2002; doi:10.1152/japplphysiol.00473.2002
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
93/5/1709    most recent
00473.2002v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Allen, G.
Right arrow Articles by Bates, J. H. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Allen, G.
Right arrow Articles by Bates, J. H. T.
Vol. 93, Issue 5, 1709-1715, November 2002

Transient mechanical benefits of a deep inflation in the injured mouse lung

Gilman Allen1, Lennart K. A. Lundblad1,2, Polly Parsons1, and Jason H. T. Bates1

1 Department of Medicine, Vermont Lung Center, University of Vermont, Burlington, Vermont 05405; and 2 Department of Clinical Physiology, Malmö University Hospital, Lund University, 20512 Malmö, Sweden

The lasting effects of a recruitment maneuver (RM) in the injured lung are not well characterized. We speculated that the reduction in respiratory elastance (H) after a deep inflation (DI) is transient in nature and should be sustained longer at higher positive end-expiratory pressure (PEEP). Thirteen ventilated mice were given 2 DIs at various levels of PEEP before and after saline lavage. Forced oscillations were used to measure H periodically over 7 min after the DIs. Time constants (tau ) were estimated for the post-DI recovery in H. Values for tau  before lavage (80-115 s) were reduced after lavage (13-30 s) at all levels of PEEP (P = 0.0001). PEEP did not significantly influence tau  before or after lavage. The plateau level and total recovery in H after a DI were significantly influenced by PEEP and lavage (P < 0.0001). Our results suggest that for a DI to be beneficial in the injured mouse lung, it may have to be applied several times a minute.

atelectasis; acute lung injury; recruitment; elastance; positive-pressure respiration


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
C. B. Massa, G. B. Allen, and J. H. T. Bates
Modeling the dynamics of recruitment and derecruitment in mice with acute lung injury
J Appl Physiol, December 1, 2008; 105(6): 1813 - 1821.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Thammanomai, L. E. Hueser, A. Majumdar, E. Bartolak-Suki, and B. Suki
Design of a new variable-ventilation method optimized for lung recruitment in mice
J Appl Physiol, May 1, 2008; 104(5): 1329 - 1340.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. D'Angelo, A. Koutsoukou, P. D. Valle, G. Gentile, and M. Pecchiari
Cytokine release, small airway injury, and parenchymal damage during mechanical ventilation in normal open-chest rats
J Appl Physiol, January 1, 2008; 104(1): 41 - 49.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. B. Allen, L. A. Pavone, J. D. DiRocco, J. H. T. Bates, and G. F. Nieman
Pulmonary impedance and alveolar instability during injurious ventilation in rats
J Appl Physiol, August 1, 2005; 99(2): 723 - 730.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. K. A. Lundblad, J. Thompson-Figueroa, T. Leclair, M. J. Sullivan, M. E. Poynter, C. G. Irvin, and J. H. T. Bates
Tumor Necrosis Factor-{alpha} Overexpression in Lung Disease: A Single Cause behind a Complex Phenotype
Am. J. Respir. Crit. Care Med., June 15, 2005; 171(12): 1363 - 1370.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. D'Angelo, M. Pecchiari, M. Saetta, E. Balestro, and J. Milic-Emili
Dependence of lung injury on inflation rate during low-volume ventilation in normal open-chest rabbits
J Appl Physiol, July 1, 2004; 97(1): 260 - 268.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Allen and J. H. T. Bates
Dynamic mechanical consequences of deep inflation in mice depend on type and degree of lung injury
J Appl Physiol, January 1, 2004; 96(1): 293 - 300.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
L. Gattinoni, E. Carlesso, P. Cadringher, F. Valenza, F. Vagginelli, and D. Chiumello
Physical and biological triggers of ventilator-induced lung injury and its prevention
Eur. Respir. J., November 16, 2003; 22(47_suppl): 15s - 25s.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. H. T. Bates and C. G. Irvin
Measuring lung function in mice: the phenotyping uncertainty principle
J Appl Physiol, April 1, 2003; 94(4): 1297 - 1306.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online