Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 93: 1384-1390, 2002. First published June 21, 2002; doi:10.1152/japplphysiol.00209.2002
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
93/4/1384    most recent
00209.2002v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Crimi, E.
Right arrow Articles by Brusasco, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Crimi, E.
Right arrow Articles by Brusasco, V.
Vol. 93, Issue 4, 1384-1390, October 2002

Deep breaths, methacholine, and airway narrowing in healthy and mild asthmatic subjects

Emanuele Crimi1, Riccardo Pellegrino2, Manlio Milanese1, and Vito Brusasco1

1 Dipartimento di Medicina Interna, Università di Genova, 16132 Genova; and 2 Fisiopatologia Respiratoria, Azienda Ospedaliera S. Croce e Carle, 12100 Cuneo, Italy

Deep breaths taken before inhalation of methacholine attenuate the decrease in forced expiratory volume in 1 s and forced vital capacity in healthy but not in asthmatic subjects. We investigated whether this difference also exists by using measurements not preceded by full inflation, i.e., airway conductance, functional residual capacity, as well as flow and residual volume from partial forced expiration. We found that five deep breaths preceding a single dose of methacholine 1) transiently attenuated the decrements in forced expiratory volume in 1 s and forced vital capacity in healthy (n = 8) but not in mild asthmatic (n = 10) subjects and 2) increased the areas under the curve of changes in parameters not preceded by a full inflation over 40 min, during which further deep breaths were prohibited, without significant difference between healthy (n = 6) and mild asthmatic (n = 16) subjects. In conclusion, a series of deep breaths preceding methacholine inhalation significantly enhances bronchoconstrictor response similarly in mild asthmatic and healthy subjects but facilitates bronchodilatation on further full inflation in the latter.

forced expiratory volume in 1 s; specific airway conductance; partial flow-volume curve; functional residual capacity; residual volume


This article has been cited by other articles:


Home page
 Eur Respir JHome page
G. Barisione, A. Bacigalupo, E. Crimi, M. T. Van Lint, T. Lamparelli, and V. Brusasco
Changes in lung volumes and airway responsiveness following haematopoietic stem cell transplantation
Eur. Respir. J., December 1, 2008; 32(6): 1576 - 1582.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. Scichilone, A. La Sala, M. Bellia, K. Fallano, A. Togias, R. H. Brown, M. Midiri, and V. Bellia
The airway response to deep inspirations decreases with COPD severity and is associated with airway distensibility assessed by computed tomography
J Appl Physiol, September 1, 2008; 105(3): 832 - 838.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
T. T. B. Nguyen and J. J. Fredberg
Strange Dynamics of a Dynamic Cytoskeleton
Proceedings of the ATS, January 1, 2008; 5(1): 58 - 61.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. B. Noble, P. K. McFawn, and H. W. Mitchell
Responsiveness of the isolated airway during simulated deep inspirations: effect of airway smooth muscle stiffness and strain
J Appl Physiol, September 1, 2007; 103(3): 787 - 795.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. M. Slats, K. Janssen, A. van Schadewijk, D. T. van der Plas, R. Schot, J. G. van den Aardweg, J. C. de Jongste, P. S. Hiemstra, T. Mauad, K. F. Rabe, et al.
Bronchial Inflammation and Airway Responses to Deep Inspiration in Asthma and Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., July 15, 2007; 176(2): 121 - 128.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. S. An, T. R. Bai, J. H. T. Bates, J. L. Black, R. H. Brown, V. Brusasco, P. Chitano, L. Deng, M. Dowell, D. H. Eidelman, et al.
Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma
Eur. Respir. J., May 1, 2007; 29(5): 834 - 860.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. Scichilone, S. Permutt, V. Bellia, and A. Togias
Inhaled Corticosteroids and the Beneficial Effect of Deep Inspiration in Asthma
Am. J. Respir. Crit. Care Med., September 15, 2005; 172(6): 693 - 699.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
B. Simard, H. Turcotte, D. W. Cockcroft, B. E. Davis, M.-E. Boulay, and L.-P. Boulet
Deep Inspiration Avoidance and Methacholine Response in Normal Subjects and Patients With Asthma
Chest, January 1, 2005; 127(1): 135 - 142.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. B. Noble, P. K. McFawn, and H. W. Mitchell
Intraluminal pressure oscillation enhances subsequent airway contraction in isolated bronchial segments
J Appl Physiol, March 1, 2004; 96(3): 1161 - 1165.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. Brusasco and R. Pellegrino
Invited Review: Complexity of factors modulating airway narrowing in vivo: relevance to assessment of airway hyperresponsiveness
J Appl Physiol, September 1, 2003; 95(3): 1305 - 1313.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online