| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Physiology and Biomedical Engineering, Norwegian University of Science and Technology, N-7489 Trondheim; and 2 Department of Cardiology, St. Olavs Hospital HF, N-7006 Trondheim, Norway
Whereas novel pathways of
pathological heart enlargement have been unveiled by thoracic aorta
constriction in genetically modified mice, the molecular mechanisms of
adaptive cardiac hypertrophy remain virtually unexplored and call for
an effective and well-characterized model of physiological mechanical
loading. Experimental procedures of maximal oxygen consumption
(
O2 max) and intensity-controlled treadmill running were established in 40 female and 36 male C57BL/6J mice. An inclination-dependent O2 max
with 0.98 test-retest correlation was found at 25° treadmill grade.
Running for 2 h/day, 5 days/wk, in intervals of 8 min at 85-90%
of O2 max and 2 min at 50% (adjusted
to weekly O2 max testing) increased
O2 max to a plateau 49% above
sedentary females and 29% in males. Running economy improved in both
sexes, and echocardiography indicated significantly increased left
ventricle posterior wall thickness. Ventricular weights
increased by 19-29 and 12-17% in females and males,
respectively, whereas cardiomyocyte dimensions increased by 20-32,
and 17-23% in females and males, respectively; skeletal muscle
mass increased by 12-18%. Thus the model mimics human responses
to exercise and can be used in future studies of molecular mechanisms
underlying these adaptations.
maximal oxygen uptake; work economy; respiratory exchange ratio; cardiomyocyte; allometric scaling
This article has been cited by other articles:
|
|
 |
|
  T. H. Meek, B. P. Lonquich, R. M. Hannon, and T. Garland Jr Endurance capacity of mice selectively bred for high voluntary wheel running J. Exp. Biol., September 15, 2009; 212(18): 2908 - 2917. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. O. Stolen, M. A. Hoydal, O. J. Kemi, D. Catalucci, M. Ceci, E. Aasum, T. Larsen, N. Rolim, G. Condorelli, G. L. Smith, et al. Interval Training Normalizes Cardiomyocyte Function, Diastolic Ca2+ Control, and SR Ca2+ Release Synchronicity in a Mouse Model of Diabetic Cardiomyopathy Circ. Res., September 11, 2009; 105(6): 527 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. F. Reardon and D. G. Allen Iron injections in mice increase skeletal muscle iron content, induce oxidative stress and reduce exercise performance Exp Physiol, June 1, 2009; 94(6): 720 - 730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Shephard, C. Foster, A. Lucia, D. R. Bassett, S. M. Marcora, J. Gonzalez-Alonso, S. P. Mortensen, S. S. Cheung, A. D. Flouris, O. J. Kemi, et al. No support for central governor. J Appl Physiol, January 1, 2009; 106(1): 343 - 344. [Full Text] [PDF]
|
|
|
|
|
|
M. Velders, K. Legerlotz, S. J. Falconer, N. S. Stott, C. D. McMahon, and H. K. Smith Effect of botulinum toxin A-induced paralysis and exercise training on mechanosensing and signalling gene expression in juvenile rat gastrocnemius muscle Exp Physiol, December 1, 2008; 93(12): 1273 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Chappell, T. Garland Jr, G. F. Robertson, and W. Saltzman Relationships among running performance, aerobic physiology and organ mass in male Mongolian gerbils J. Exp. Biol., December 1, 2007; 210(23): 4179 - 4197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Raher, H. Thibault, K. K. Poh, R. Liu, E. F. Halpern, G. Derumeaux, F. Ichinose, W. M. Zapol, K. D. Bloch, M. H. Picard, et al. In Vivo Characterization of Murine Myocardial Perfusion With Myocardial Contrast Echocardiography: Validation and Application in Nitric Oxide Synthase 3 Deficient Mice Circulation, September 11, 2007; 116(11): 1250 - 1257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Schultz, J. G. Swallow, R. P. Waters, J. A. Kuzman, R. A. Redetzke, S. Said, G. M. de Escobar, and A. M. Gerdes Effects of Excessive Long-Term Exercise on Cardiac Function and Myocyte Remodeling in Hypertensive Heart Failure Rats Hypertension, August 1, 2007; 50(2): 410 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Chow, L. J. Greenlund, Y. W. Asmann, K. R. Short, S. K. McCrady, J. A. Levine, and K. S. Nair Impact of endurance training on murine spontaneous activity, muscle mitochondrial DNA abundance, gene transcripts, and function J Appl Physiol, March 1, 2007; 102(3): 1078 - 1089. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. S. Evangelista and J. E. Krieger Small gene effect and exercise training-induced cardiac hypertrophy in mice: an Ace gene dosage study Physiol Genomics, November 21, 2006; 27(3): 231 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Rezende, T. Garland Jr, M. A. Chappell, J. L. Malisch, and F. R. Gomes Maximum aerobic performance in lines of Mus selected for high wheel-running activity: effects of selection, oxygen availability and the mini-muscle phenotype J. Exp. Biol., January 1, 2006; 209(1): 115 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Choi, X. Liu, P. Li, T. Akimoto, S. Y. Lee, M. Zhang, and Z. Yan Transcriptional profiling in mouse skeletal muscle following a single bout of voluntary running: evidence of increased cell proliferation J Appl Physiol, December 1, 2005; 99(6): 2406 - 2415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Andrade, J. T. Lam, M. Zamora, C. Huang, D. Franco, N. Sevilla, P. J. Gruber, J. T. Lu, and P. Ruiz-Lozano Predominant fusion of bone marrow-derived cardiomyocytes Cardiovasc Res, December 1, 2005; 68(3): 387 - 393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Diaz, C. K. Thomas, S. Garcia, D. Hernandez, and C. T. Moraes Mice lacking COX10 in skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency Hum. Mol. Genet., September 15, 2005; 14(18): 2737 - 2748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. J. Kemi, P. M. Haram, J. P. Loennechen, J.-B. Osnes, T. Skomedal, U. Wisloff, and O. Ellingsen Moderate vs. high exercise intensity: Differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function Cardiovasc Res, July 1, 2005; 67(1): 161 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Rezende, M. A. Chappell, F. R. Gomes, J. L. Malisch, and T. Garland Jr Maximal metabolic rates during voluntary exercise, forced exercise, and cold exposure in house mice selectively bred for high wheel-running J. Exp. Biol., June 15, 2005; 208(12): 2447 - 2458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Mehl, J. M. Davis, J. M. Clements, F. G. Berger, M. M. Pena, and J. A. Carson Decreased intestinal polyp multiplicity is related to exercise mode and gender in ApcMin/+ mice J Appl Physiol, June 1, 2005; 98(6): 2219 - 2225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Billat, E. Mouisel, N. Roblot, and J. Melki Inter- and intrastrain variation in mouse critical running speed J Appl Physiol, April 1, 2005; 98(4): 1258 - 1263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Massett and B. C. Berk Strain-dependent differences in responses to exercise training in inbred and hybrid mice Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R1006 - R1013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. I. Gustafsson, K. Tommeras, I. Nordrum, J. P. Loennechen, A. Brunsvik, E. Solligard, R. Fossmark, I. Bakke, U. Syversen, and H. Waldum Long-Term Serotonin Administration Induces Heart Valve Disease in Rats Circulation, March 29, 2005; 111(12): 1517 - 1522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Reboul, S. Tanguy, J. M. Juan, M. Dauzat, and P. Obert Cardiac remodeling and functional adaptations consecutive to altitude training in rats: implications for sea level aerobic performance J Appl Physiol, January 1, 2005; 98(1): 83 - 92. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Selvetella, E. Hirsch, A. Notte, G. Tarone, and G. Lembo Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence Cardiovasc Res, August 15, 2004; 63(3): 373 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. J. Kemi, P. M. Haram, U. Wisloff, and O. Ellingsen Aerobic Fitness Is Associated With Cardiomyocyte Contractile Capacity and Endothelial Function in Exercise Training and Detraining Circulation, June 15, 2004; 109(23): 2897 - 2904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Faldt, I. Wernstedt, S. M. Fitzgerald, K. Wallenius, G. Bergstrom, and J.-O. Jansson Reduced Exercise Endurance in Interleukin-6-Deficient Mice Endocrinology, June 1, 2004; 145(6): 2680 - 2686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kubica, S. R. Kimball, L. S. Jefferson, and P. A. Farrell Alterations in the expression of mRNAs and proteins that code for species relevant to eIF2B activity after an acute bout of resistance exercise J Appl Physiol, February 1, 2004; 96(2): 679 - 687. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
