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1 Department of Anesthesiology and General Clinical Research Center, Mayo Clinic and Foundation, Rochester, Minnesota 55905; and 2 Department of Exercise and Movement Science, University of Oregon, Eugene, Oregon 97403-1240
We tested the
hypothesis that acute hypoxia would alter the sensitivity of arterial
baroreflex control of both heart rate and sympathetic vasoconstrictor
outflow. In 16 healthy, nonsmoking, normotensive subjects (8 women, 8 men, age 20-33 yr), we assessed baroreflex control of heart rate
and muscle sympathetic nerve activity by using the modified Oxford
technique during both normoxia and hypoxia (12%
O2). Compared with normoxia, hypoxia reduced arterial O2 saturation levels from 96.8 ± 0.3 to
80.7 ± 1.4% (P < 0.001), increased heart rate from
59.8 ± 2.4 to 79.4 ± 2.9 beats/min (P < 0.001),
increased mean arterial pressure from 96.7 ± 2.5 to 105.0 ± 3.3 mmHg (P = 0.002), and increased sympathetic activity 126 ± 58% (P < 0.05). The sensitivity for
baroreflex control of both heart rate and sympathetic activity was not
altered by hypoxia (heart rate: 
1.02 ± 0.09 vs. 1.02 ± 0.11 beats · min
1 · mmHg1;
nerve activity: 5.6 ± 0.9 vs. 6.2 ± 0.9 integrated
activity · beat1 · mmHg1;
both P > 0.05). Acute exposure to hypoxia reset
baroreflex control of both heart rate and sympathetic activity to
higher pressures without changes in baroreflex sensitivity.
altitude; anoxia; sympathetic nervous system; syncope; orthostasis
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