Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 93: 161-166, 2002. First published April 5, 2002; doi:10.1152/japplphysiol.01084.2001
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
93/1/161    most recent
01084.2001v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yamauchi, K.
Right arrow Articles by Kulkarni, A. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamauchi, K.
Right arrow Articles by Kulkarni, A. D.
Vol. 93, Issue 1, 161-166, July 2002

Dietary nucleotides prevent decrease in cellular immunity in ground-based microgravity analog

Keiko Yamauchi1, Nathan W. Hales1, Sandra M. Robinson2, Michael L. Niehoff2, Vani Ramesh1, Neal R. Pellis3, and Anil D. Kulkarni1,2

1 Department of Surgery, University of Texas Health Science Center Houston, Houston 77030; 3 Cellular Biotechnology, Johnson Space Center/National Aeronautics and Space Administration, Houston, Texas 77058; and 2 Department of Surgery, Saint Louis School of Medicine, St. Louis, Missouri 63104

Microgravity and stress of spaceflights result in immune dysfunction. The role of nutrition, especially nucleotide supplementation, has become an area of intensive research and significant interest in immunomodulation for maintenance of cellular immune responses. The studies presented here evaluate the plausibility of administering nucleotides to obviate immune dysfunction in an Earth-based in vivo analog of microgravity as studied in anti-orthostatic tail suspension (AOS) of mice. Mice were divided into three housing groups: group, isolation, and AOS. Mice were fed either control chow diet (CD), or RNA-, adenine-, or uracil-supplemented CD for the 1-wk duration of the experiments. In AOS mice, supplemental nucleotides significantly increased in vivo lymph node proliferation and ex vivo lymphoproliferation response to alloantigen and mitogens, respectively, and interleukin-2 and interferon-gamma production. A lower corticosterone level was observed in uracil-supplemented CD compared with CD. These results suggest that exogenous nucleotide supplementation, especially uracil, of normal diet is beneficial in the maintenance and restoration of the immune response during the microgravity analog conditions.

nutrition; microgravity; mice


This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
N. Gueguinou, C. Huin-Schohn, M. Bascove, J.-L. Bueb, E. Tschirhart, C. Legrand-Frossi, and J.-P. Frippiat
Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth's orbit?
J. Leukoc. Biol., November 1, 2009; 86(5): 1027 - 1038.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. J. Pecaut, G. M. Miller, G. A. Nelson, and D. S. Gridley
Hypergravity-induced immunomodulation in a rodent model: hematological and lymphocyte function analyses
J Appl Physiol, July 1, 2004; 97(1): 29 - 38.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online