Journal of Applied Physiology Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 93: 116-126, 2002. First published March 8, 2002; doi:10.1152/japplphysiol.01095.2001
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
93/1/116    most recent
01095.2001v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (19)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wetter, T. J.
Right arrow Articles by Dempsey, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wetter, T. J.
Right arrow Articles by Dempsey, J. A.
Vol. 93, Issue 1, 116-126, July 2002

Role of lung inflammatory mediators as a cause of exercise-induced arterial hypoxemia in young athletes

Thomas J. Wetter1, Zhuzai Xiang2, David A. Sonetti1, Hans C. Haverkamp1, Anthony J. Rice1, Adnan A. Abbasi2, Keith C. Meyer2, and Jerome A. Dempsey1

1 John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, and 2 Department of Medicine, Section of Pulmonary and Critical Care Medicine, Clinical Sciences Center, University of Wisconsin, Madison, Wisconsin 53705

We examined whether lung inflammatory mediators are increased during exercise and whether pharmacological blockade can prevent exercise-induced arterial hypoxemia (EIAH) in young athletes. Seventeen healthy athletes (9 men, 8 women; age 23 ± 3 yr) with varying degrees of EIAH completed maximal incremental treadmill exercise tests after administration of fexofenadine, zileuton, and nedocromil sodium or placebo in a randomized double-blind crossover study. Lung function, arterial blood gases, and inflammatory metabolites in plasma, urine, and induced sputum were assessed. Drug administration did not improve EIAH or gas exchange during exercise. At maximal exercise, oxygen saturation fell to 91.4 ± 2.6% (drug trial) and 91.9 ± 2.1% (placebo trial) and alveolar-arterial oxygen difference widened to 28.1 ± 6.3 Torr (drug trial) and 29.3 ± 5.7 Torr (placebo trial). Oxygen consumption, ventilation, and other exercise variables were similarly unaffected by drug treatment. Although plasma histamine increased with exercise, values did not differ between trials, and urinary leukotriene E4 and 11beta -prostaglandin F2alpha levels were unchanged after exercise. Postexercise sputum revealed no significant changes in markers of inflammation. These results demonstrate that EIAH in young athletes is not attenuated with acute administration of drugs targeting histamine and bioactive lipids. We conclude that airway inflammation is of insufficient magnitude to cause impairments in gas exchange and does not appear to be linked to EIAH in healthy young athletes.

histamine; leukotrienes; prostaglandins; pulmonary gas exchange; respiratory resistance; arterial blood gases


This article has been cited by other articles:


Home page
 Br. J. Sports. Med.Home page
A N H Hodges, B M Lynn, M S Koehle, and D C McKenzie
Effects of inhaled bronchodilators and corticosteroids on exercise induced arterial hypoxaemia in trained male athletes
Br. J. Sports Med., December 1, 2005; 39(12): 917 - 920.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. C. Haverkamp, J. A. Dempsey, J. D. Miller, L. M. Romer, D. F. Pegelow, J. R. Rodman, and M. W. Eldridge
Gas exchange during exercise in habitually active asthmatic subjects
J Appl Physiol, November 1, 2005; 99(5): 1938 - 1950.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. K. Grissom, L. D. Richer, and M. R. Elstad
The Effects of a 5-Lipoxygenase Inhibitor on Acute Mountain Sickness and Urinary Leukotriene E4 After Ascent to High Altitude
Chest, February 1, 2005; 127(2): 565 - 570.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Manohar, T. E. Goetz, and A. S. Hassan
NaHCO3 does not affect arterial O2 tension but attenuates desaturation of hemoglobin in maximally exercising Thoroughbreds
J Appl Physiol, April 1, 2004; 96(4): 1349 - 1356.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Manohar, T. E. Goetz, and A. S. Hassan
Preexercise hypervolemia does not affect arterial hypoxemia in Thoroughbreds performing short-term high-intensity exercise
J Appl Physiol, June 1, 2003; 94(6): 2135 - 2144.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online