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J Appl Physiol 92: 2547-2553, 2002. First published January 18, 2002; doi:10.1152/japplphysiol.01263.2001
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Vol. 92, Issue 6, 2547-2553, June 2002

Enhanced plasma IL-6 and IL-1ra responses to repeated vs. single bouts of prolonged cycling in elite athletes

Ola Ronsen1, Tor Lea2, Roald Bahr3, and Bente Klarlund Pedersen4

1 Norwegian Olympic Sports Center and 3 Norwegian University of Sports and Physical Education, 0806 Oslo; and 2 Institute of Immunology, Rikshospitalet University Hospital, 0027 Oslo, Norway; and 4 Copenhagen Muscle Research Center and Rigshospitalet University Hospital, 2200 Copenhagen, Denmark

The impact of repeated bouts of exercise on plasma levels of interleukin (IL)-6 and IL-1 receptor antagonist (IL-1ra) was examined. Nine well-trained men participated in four different 24-h trials: Long [two bouts of exercise, at 0800-0915 and afternoon exercise (Ex-A), separated by 6 h]; Short (two bouts, at 1100-1215 and Ex-A, separated by 3 h); One (single bout performed at the same Ex-A as second bout in prior trials); and Rest (no exercise). All exercise bouts were performed on a cycle ergometer at 75% of maximal O2 uptake and lasted 75 min. Peak IL-6 observed at the end of Ex-A was significantly higher in Short (8.8 ± 1.3 pg/ml) than One (5.2 ± 0.7 pg/ml) but not compared with Long (5.9 ± 1.2 pg/ml). Peak IL-1ra observed 1 h postexercise was significantly higher in Short (1,774 ± 373 pg/ml) than One (302 ± 53 pg/ml) but not compared with Long (1,276 ± 451 pg/ml). We conclude that, when a second bout of endurance exercise is performed after only 3 h of recovery, IL-6 and IL-1ra responses are elevated. This may be linked to muscle glycogen depletion.

glucose; recovery; muscle; glycogen


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