Journal of Applied Physiology Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 92: 1911-1922, 2002. First published January 11, 2002; doi:10.1152/japplphysiol.00936.2001
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
92/5/1911    most recent
00936.2001v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bestle, M. H.
Right arrow Articles by Bie, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bestle, M. H.
Right arrow Articles by Bie, P.
Vol. 92, Issue 5, 1911-1922, May 2002

Prolonged hypobaric hypoxemia attenuates vasopressin secretion and renal response to osmostimulation in men

Morten H. Bestle1,2, Niels V. Olsen3, Troels D. Poulsen2, Robert Roach4, Niels Fogh-Andersen5, and Peter Bie6

1 Departments of Clinical Physiology and 5 Clinical Chemistry, Herlev Hospital, University of Copenhagen, DK-2730 Herlev; 2 Department of Anesthesia and Intensive Care, Gentofte Hospital, University of Copenhagen, DK-2900 Hellerup; 3 Department of Neuroanesthesia, and 4 Copenhagen Muscle Research Centre, Copenhagen University Hospital, DK-2100 Copenhagen; and 6 Department of Medical Biology, University of Southern Denmark, Odense, DK-5000 Odense, Denmark

Effects of hypobaric hypoxemia on endocrine and renal parameters of body fluid homeostasis were investigated in eight normal men during a sojourn of 8 days at an altitude of 4,559 m. Endocrine and renal responses to an osmotic stimulus (5% hypertonic saline, 3.6 ml/kg over 1 h) were investigated at sea level and on day 6 at altitude. Several days of hypobaric hypoxemia reduced body weight (-2.1 ± 0.4 kg), increased plasma osmolality (+5.3 ± 1.4 mosmol/kgH2O), elevated blood pressure (+12 ± 1 mmHg), reduced creatinine clearance (122 ± 6 to 96 ± 10 ml/min), inhibited the renin system (19.5 ± 2.0 to 10.9 ± 0.9 mU/l) and plasma vasopressin (1.14 ± 0.16 to 0.38 ± 0.06 pg/ml), and doubled circulating levels of norepinephrine (103 ± 16 to 191 ± 35 pg/ml) and endothelin-1 (3.0 ± 0.2 to 6.3 ± 0.6 pg/ml), whereas urodilatin excretion rate decreased from day 2 (all changes P < 0.05 compared with sea level). Plasma arginine vasopressin response and the antidiuretic response to hypertonic saline loading were unchanged, but the natriuretic response was attenuated. In conclusion, chronic hypobaric hypoxemia 1) elevates the set point of plasma osmolality-to-plasma vasopressin relationship, possibly because of concurrent hypertension, thereby causing hypovolemia and hyperosmolality, and 2) blunts the natriuretic response to hypertonic volume expansion, possibly because of elevated circulating levels of norepinephrine and endothelin, reduced urodilatin synthesis, or attenuated inhibition of the renin system.

endothelin-1; hypertonic saline; sodium excretion; urodilatin


This article has been cited by other articles:


Home page
 ChestHome page
C. K. Grissom, L. D. Richer, and M. R. Elstad
The Effects of a 5-Lipoxygenase Inhibitor on Acute Mountain Sickness and Urinary Leukotriene E4 After Ascent to High Altitude
Chest, February 1, 2005; 127(2): 565 - 570.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. M. Maresh, W. J. Kraemer, D. A. Judelson, J. L. VanHeest, L. Trad, J. M. Kulikowich, K. L. Goetz, A. Cymerman, and A. J. Hamilton
Effects of high altitude and water deprivation on arginine vasopressin release in men
Am J Physiol Endocrinol Metab, January 1, 2004; 286(1): E20 - E24.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online