Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 92: 1873-1878, 2002. First published December 21, 2001; doi:10.1152/japplphysiol.01055.2001
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
92/5/1873    most recent
01055.2001v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (36)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pizza, F. X.
Right arrow Articles by Brooks, S. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pizza, F. X.
Right arrow Articles by Brooks, S. V.
Vol. 92, Issue 5, 1873-1878, May 2002

Muscle inflammatory cells after passive stretches, isometric contractions, and lengthening contractions

Francis X. Pizza1,*, Timothy J. Koh2,*, Stephen J. McGregor1, and Susan V. Brooks2

1 Department of Kinesiology, The University of Toledo, Toledo, Ohio 43606-3390; and 2 Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109-2007

We tested the hypotheses that lengthening contractions, isometric contractions, and passive stretches increase muscle inflammatory cells (neutrophils and macrophages) and that prior conditioning with lengthening contractions, isometric contractions, or passive stretches reduces neutrophils and macrophages after subsequent lengthening contractions. Extensor digitorum longus muscles in anesthetized mice were subjected in situ to lengthening contractions, isometric contractions, or passive stretches. Six hours or 3 days after a protocol of contractions or passive stretches, neutrophils and macrophages were quantified in muscle cross sections. Three days after isometric contractions or passive stretches, neutrophils were elevated (P < 0.05) 3.7- and 5.5-fold, respectively, relative to controls. Both macrophages and neutrophils were increased 51.2- and 7.9-fold, respectively, after lengthening contractions. Prior lengthening contractions, isometric contractions, or passive stretches reduced inflammatory cells after lengthening contractions performed 2 wk later. The major finding of this study was that passive stretches and isometric contractions elevated neutrophils without causing overt signs of injury. Because both passive stretches and isometric contractions elevated neutrophils and afforded some protection from contraction-induced muscle injury, neutrophils and/or the related inflammatory events may contribute to the induction of a protective mechanism.

neutrophils; macrophages; muscle injury; muscle degeneration

* F. X. Pizza and T. J. Koh are co-first authors.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
N. C. Lockhart and S. V. Brooks
Neutrophil accumulation following passive stretches contributes to adaptations that reduce contraction-induced skeletal muscle injury in mice
J Appl Physiol, April 1, 2008; 104(4): 1109 - 1115.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
D. M. DiPasquale, M. Cheng, W. Billich, S. A. Huang, N. van Rooijen, T. A. Hornberger, and T. J. Koh
Urokinase-type plasminogen activator and macrophages are required for skeletal muscle hypertrophy in mice
Am J Physiol Cell Physiol, October 1, 2007; 293(4): C1278 - C1285.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. A. Smith, F. Stauber, C. Waters, S. E. Alway, and W. T. Stauber
Transforming growth factor-beta following skeletal muscle strain injury in rats
J Appl Physiol, February 1, 2007; 102(2): 755 - 761.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. M. Peterson, K. D. Feeback, J. H. Baas, and F. X. Pizza
Tumor necrosis factor-{alpha} promotes the accumulation of neutrophils and macrophages in skeletal muscle
J Appl Physiol, November 1, 2006; 101(5): 1394 - 1399.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
E. P. Rader, W. Song, H. Van Remmen, A. Richardson, and J. A. Faulkner
Raising the antioxidant levels within mouse muscle fibres does not affect contraction-induced injury
Exp Physiol, July 1, 2006; 91(4): 781 - 789.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
N. C. Lockhart and S. V. Brooks
Protection from contraction-induced injury provided to skeletal muscles of young and old mice by passive stretch is not due to a decrease in initial mechanical damage.
J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2006; 61(6): 527 - 533.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
B. A. Bondesen, S. T. Mills, and G. K. Pavlath
The COX-2 pathway regulates growth of atrophied muscle via multiple mechanisms
Am J Physiol Cell Physiol, June 1, 2006; 290(6): C1651 - C1659.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
X. Wang, T-X. Jiang, J. D. Road, D. M. Redenbach, and W. D. Reid
Granulocytosis and increased adhesion molecules after resistive loading of the diaphragm
Eur. Respir. J., November 1, 2005; 26(5): 786 - 794.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. J. Koh, S. C. Bryer, A. M. Pucci, and T. H. Sisson
Mice deficient in plasminogen activator inhibitor-1 have improved skeletal muscle regeneration
Am J Physiol Cell Physiol, July 1, 2005; 289(1): C217 - C223.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. K. Tsivitse, E. Mylona, J. M. Peterson, W. T. Gunning, and F. X. Pizza
Mechanical loading and injury induce human myotubes to release neutrophil chemoattractants
Am J Physiol Cell Physiol, March 1, 2005; 288(3): C721 - C729.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
F. X Pizza, J. M Peterson, J. H Baas, and T. J Koh
Neutrophils contribute to muscle injury and impair its resolution after lengthening contractions in mice
J. Physiol., February 1, 2005; 562(3): 899 - 913.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
I. A. Barash, L. Mathew, A. F. Ryan, J. Chen, and R. L. Lieber
Rapid muscle-specific gene expression changes after a single bout of eccentric contractions in the mouse
Am J Physiol Cell Physiol, February 1, 2004; 286(2): C355 - C364.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
Y.-W. Chen, M. J. Hubal, E. P. Hoffman, P. D. Thompson, and P. M. Clarkson
Molecular responses of human muscle to eccentric exercise
J Appl Physiol, December 1, 2003; 95(6): 2485 - 2494.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
T. Raastad, B. A. Risoy, H. B. Benestad, J. G. Fjeld, and J. Hallen
Temporal relation between leukocyte accumulation in muscles and halted recovery 10-20 h after strength exercise
J Appl Physiol, December 1, 2003; 95(6): 2503 - 2509.
[Abstract] [Full Text]

Home page
 Br. J. Sports. Med.Home page
H Toumi and T M Best
The inflammatory response: friend or enemy for muscle injury?
Br. J. Sports Med., August 1, 2003; 37(4): 284 - 286.
[Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
T. J. Koh, J. M. Peterson, F. X. Pizza, and S. V. Brooks
Passive Stretches Protect Skeletal Muscle of Adult and Old Mice From Lengthening Contraction-Induced Injury
J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2003; 58(7): B592 - 597.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. J. McLoughlin, E. Mylona, T. A. Hornberger, K. A. Esser, and F. X. Pizza
Inflammatory cells in rat skeletal muscle are elevated after electrically stimulated contractions
J Appl Physiol, March 1, 2003; 94(3): 876 - 882.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online