| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Veterinary Biosciences, 2 Dorothy M. Davis Heart and Lung Research Institute, and 4 Department of Food Science and Technology, The Ohio State University, Columbus, Ohio 43210; and 3 Tufts University Department of Biomedical Science, North Grafton, Massachusetts 01536
Sexual dimorphism may occur during the development of hypertension and congestive heart failure (CHF). Male and female spontaneous hypertension heart failure (SHHF) rats with established hypertension, but before CHF (age 5-8 mo) and during cardiac decompensation leading to CHF (age 18-20 mo in male rats and 22-24 mo in female rats), were studied. At 5-8 mo, male SHHF rats showed early activation of the renin-angiotensin system (RAS), as indicated by increased plasma renin activity (PRA) and higher serum angiotensin-converting enzyme activity compared with female rats. The increase in PRA in female rats was delayed compared with males rats, but it reached comparable levels just before CHF. Urinary endothelin excretion was significantly greater in 5- to 8-mo-old female rats compared with age-matched male rats. Urinary endothelin excretion increased in both male and female rats as CHF developed. Plasma atrial natriuretic peptide (ANP) was comparable at both time points, and both genders showed similar, marked increases as CHF developed. In conclusion, male rats show early activation of the RAS, whereas female rats show early activation of the endothelin vasopressor system. During cardiac decompensation, generalized activation of the RAS, endothelin, and ANP systems occurs and is similar in male and female SHHF rats.
plasma renin activity; atrial natriuretic peptide; spontaneous hypertension heart failure
This article has been cited by other articles:
|
|
 |
|
  L. Groban, L. M. Yamaleyeva, B. M. Westwood, T. T. Houle, M. Lin, D. W. Kitzman, and M. C. Chappell Progressive Diastolic Dysfunction in the Female mRen(2).Lewis Rat: Influence of Salt and Ovarian Hormones J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2008; 63(1): 3 - 11. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. F. Renna, S. M. MacDonnell, P. O. Reger, D. L. Crabbe, S. R. Houser, and J. R. Libonati Relative systolic dysfunction in female spontaneously hypertensive rat myocardium J Appl Physiol, July 1, 2007; 103(1): 353 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Chappell, L. M. Yamaleyeva, and B. M. Westwood Estrogen and salt sensitivity in the female mRen(2).Lewis rat Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1557 - R1563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Emter, S. A. McCune, G. C. Sparagna, M. J. Radin, and R. L. Moore Low-intensity exercise training delays onset of decompensated heart failure in spontaneously hypertensive heart failure rats Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2030 - H2038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. F. Ba, T. Shimizu, L. Szalay, K. I. Bland, and I. H. Chaudry Gender differences in small intestinal perfusion following trauma hemorrhage: the role of endothelin-1 Am J Physiol Gastrointest Liver Physiol, May 1, 2005; 288(5): G860 - G865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Schlenker, C. K. Kost Jr., and M. M. Likness Effects of long-term captopril and L-arginine treatment on ventilation and blood pressure in obese male SHHF rats J Appl Physiol, September 1, 2004; 97(3): 1032 - 1039. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Park, Y. Liu-Stratton, L. C. Medeiros, S. A. Mccune, and M. J. Radin Effect of Male Sex and Obesity on Platelet Arachidonic Acid in Spontaneous Hypertensive Heart Failure Rats Experimental Biology and Medicine, July 1, 2004; 229(7): 657 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. F. Ba, Y. Yokoyama, B. Toth, L. W. Rue III, K. I. Bland, and I. H. Chaudry Gender differences in small intestinal endothelial function: inhibitory role of androgens Am J Physiol Gastrointest Liver Physiol, March 1, 2004; 286(3): G452 - G457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Schlenker, T. Tamura, and A. M. Gerdes Gender-specific effects of thyroid hormones on cardiopulmonary function in SHHF rats J Appl Physiol, December 1, 2003; 95(6): 2292 - 2298. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Kacimi and A. M. Gerdes Alterations in G Protein and MAP Kinase Signaling Pathways During Cardiac Remodeling in Hypertension and Heart Failure Hypertension, April 1, 2003; 41(4): 968 - 977. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Funke-Kaiser, F. Reichenberger, K. Kopke, S.-M. Herrmann, J. Pfeifer, H.-D. Orzechowski, W. Zidek, M. Paul, and E. Brand Differential binding of transcription factor E2F-2 to the endothelin-converting enzyme-1b promoter affects blood pressure regulation Hum. Mol. Genet., February 15, 2003; 12(4): 423 - 433. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
