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J Appl Physiol 92: 1074-1082, 2002. First published November 16, 2001; doi:10.1152/japplphysiol.00613.2001
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Vol. 92, Issue 3, 1074-1082, March 2002

Effects of postnatal maturation on energetics and cross-bridge properties in rat diaphragm

Gilles Orliaguet1, Olivier Langeron2, Belaid Bouhemad2, Pierre Coriat2, Yves LeCarpentier3, and Bruno Riou2,4

1 Department of Anesthesiology and Critical Care, Centre Hospitalo-Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris V 75743 Paris Cedex 15; 2 Department of Anesthesiology and Critical Care, 4 Department of Emergency Medicine and Surgery, Centre Hospitalo-Universitaire Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie 75651 Paris Cedex 13; 3 Department of Physiology, Centre Hospitalo-Universitaire Bicêtre, Assistance Publique-Hôpitaux de Paris, Université Paris XI, Le Kremlin-Bicêtre 94270, France

The effects of maturation on cross-bridge (CB) properties were studied in rat diaphragm strips obtained at postnatal days 3, 10, and 17 and in adults (10-12 wk old). Calculations of muscle energetics and characteristics of CBs were determined from standard Huxley equations. Maturation did not change the curvature of the force-velocity relationship or the peak of mechanical efficiency. There was a significant increase in the total number of CBs per cross-sectional area (m) with aging but not in single CB force. The turnover rate of myosin ATPase increased, the duration of the CB cycle decreased, and the velocity of CBs decreased significantly only after the first week postpartum. There was a linear relationship between maximum total force and m (r = 0.969, P < 0.001), and between maximum unloaded shortening velocity and m (r = 0.728, P < 0.001). When this study in the rat and previous study in the hamster are compared, it appears that there are few species differences in the postnatal maturation process of the diaphragm.

skeletal muscle; development; cross-bridge cycling


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