Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 92: 1019-1028, 2002. First published October 26, 2001; doi:10.1152/japplphysiol.00381.2001
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
92/3/1019    most recent
00381.2001v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (14)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shore, S. A.
Right arrow Articles by Krishna Murthy, G. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shore, S. A.
Right arrow Articles by Krishna Murthy, G. G.
Vol. 92, Issue 3, 1019-1028, March 2002

Ozone-induced airway hyperresponsiveness is reduced in immature mice

S. A. Shore, R. A. Johnston, I. N. Schwartzman, D. Chism, and G. G. Krishna Murthy

Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115

During ozone (O3) exposure, adult mice decrease their minute ventilation (VE). To determine whether there are age-related differences in the ventilatory response to O3, A/J mice, aged 2, 4, 8, or 12 wk, were exposed to O3 (0.3-3.0 parts/million for 3 h) in nose-only exposure plethysmographs. Baseline VE normalized for body weight (VE/g) decreased with increasing age, consistent with the higher metabolic rates of younger animals. O3 caused a concentration-related decrease in VE in mice of all ages, but the response was significantly less in 2-wk-old than in older mice. The increased baseline VE/g and smaller decrements in VE induced by O3 in immature mice resulted in an inhaled dose of O3 normalized for body weight that was three to four times higher than in adult mice. O3 exposure caused a dose-related increase in airway responsiveness in 8- and 12-wk-old mice but did not cause airway hyperresponsiveness at any dose in either 2- or 4-wk-old mice, although higher inhaled doses of O3 normalized for body weight were delivered to these younger animals. Interleukin-6 and macrophage inflammatory protein-2 levels in bronchoalveolar lavage fluid were also increased in 8-wk-old compared with 2-wk-old mice exposed to O3. The results suggest that immature mice are less sensitive than adult mice to O3, at least in terms of the ability of O3 to induce airway hyperresponsiveness and promote release of certain cytokines.

ventilation; ontogeny; bronchoconstriction; tumor necrosis factor-alpha ; interleukin-6; macrophage inflammatory protein-2; polymorphonuclear leukocytes


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. Damera, H. Zhao, M. Wang, M. Smith, C. Kirby, W. F. Jester, J. A. Lawson, and R. A. Panettieri Jr.
Ozone modulates IL-6 secretion in human airway epithelial and smooth muscle cells
Am J Physiol Lung Cell Mol Physiol, April 1, 2009; 296(4): L674 - L683.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. A. Shore, E. S. Williams, and M. Zhu
No effect of metformin on the innate airway hyperresponsiveness and increased responses to ozone observed in obese mice
J Appl Physiol, October 1, 2008; 105(4): 1127 - 1133.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M. Pichavant, S. Goya, E. H. Meyer, R. A. Johnston, H. Y. Kim, P. Matangkasombut, M. Zhu, Y. Iwakura, P. B. Savage, R. H. DeKruyff, et al.
Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17
J. Exp. Med., February 18, 2008; 205(2): 385 - 393.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. S. Williams, S.-Y. Leung, P. Nath, N. M. Khorasani, P. Bhavsar, R. Issa, J. A. Mitchell, I. M. Adcock, and K. F. Chung
Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia
J Appl Physiol, October 1, 2007; 103(4): 1189 - 1195.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. A. Johnston, J. P. Mizgerd, L. Flynt, L. J. Quinton, E. S. Williams, and S. A. Shore
Type I Interleukin-1 Receptor Is Required for Pulmonary Responses to Subacute Ozone Exposure in Mice
Am. J. Respir. Cell Mol. Biol., October 1, 2007; 37(4): 477 - 484.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
A. S. Williams, R. Issa, S. Y. Leung, P. Nath, G. D. Ferguson, B. L. Bennett, I. M. Adcock, and K. F. Chung
Attenuation of Ozone-Induced Airway Inflammation and Hyper-Responsiveness by c-Jun NH2 Terminal Kinase Inhibitor SP600125
J. Pharmacol. Exp. Ther., July 1, 2007; 322(1): 351 - 359.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. A. Johnston, T. A. Theman, R. D. Terry, E. S. Williams, and S. A. Shore
Pulmonary responses to acute ozone exposure in fasted mice: effect of leptin administration
J Appl Physiol, January 1, 2007; 102(1): 149 - 156.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. L. S. Lofgren, M. R. Mazan, E. P. Ingenito, K. Lascola, M. Seavey, A. Walsh, and A. M. Hoffman
Restrained whole body plethysmography for measure of strain-specific and allergen-induced airway responsiveness in conscious mice
J Appl Physiol, November 1, 2006; 101(5): 1495 - 1505.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. A. Johnston, T. A. Theman, and S. A. Shore
Augmented responses to ozone in obese carboxypeptidase E-deficient mice
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R126 - R133.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. A. Johnston, I. N. Schwartzman, L. Flynt, and S. A. Shore
Role of interleukin-6 in murine airway responses to ozone
Am J Physiol Lung Cell Mol Physiol, February 1, 2005; 288(2): L390 - L397.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. A. Johnston, J. P. Mizgerd, and S. A. Shore
CXCR2 is essential for maximal neutrophil recruitment and methacholine responsiveness after ozone exposure
Am J Physiol Lung Cell Mol Physiol, January 1, 2005; 288(1): L61 - L67.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. Tamaoki, E. Tagaya, K. Kawatani, J. Nakata, Y. Endo, and A. Nagai
Airway Mucosal Thickening and Bronchial Hyperresponsiveness Induced by Inhaled {beta}2-Agonist in Mice
Chest, July 1, 2004; 126(1): 205 - 212.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. A. Shore, Y. M. Rivera-Sanchez, I. N. Schwartzman, and R. A. Johnston
Responses to ozone are increased in obese mice
J Appl Physiol, September 1, 2003; 95(3): 938 - 945.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online